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INFERTILITY

INFERTILITY

Genetic defect prevents sperm from “swimming” normally

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As more and more couples seek help with fertility issues, scientists hope to find out factors that can increase fertility.In a study published in the journal PNAS, a team led by researchers at Osaka University described an exciting breakthrough that could help future fertility therapies.After all, sperm have only one job: fertilize the egg.To do this, however, they must first enter the fallopian tube, which requires the “tail” boost of sperm.As they approach their destination, sperm swim towards the eggs through the process of “capacitation”, in which the flow of calcium ions into the flagella triggers an increase in sperm motility.Although researchers have known that an electrical signal-sensing protein called VSP is expressed in the sperm of many animals, the actual physiological role of this protein is unknown.The study’s lead author Takafumi Kawai explained: “Determining the physiological role of VSP is our main goal. To this end, we constructed a VSP-deficient mouse strain so that we can examine VSP-deficient sperm in these animals.”The first thing to notice is that the ability of sperm lacking VSP to fertilize eggs in vitro is greatly reduced.Close inspection revealed that the sperm constantly swims around during the capacitation process and cannot move forward.This means fewer sperm actually reach their destination.Motility deficits indicate problems with flagella, which has prompted researchers to examine these structures in more detail.Dr. Kawai said: “Surprisingly, in normal sperm, lipid molecules called PIP2 are concentrated near the top of the flagella, closer to the head.” “In sperm lacking VSP, PIP2 is more in the flagellaRicher and more widely distributed. In addition, the concentration of calcium ions in sperm lacking VSP is higher. “These findings indicate that VSP plays a major role in ion channel regulation and ultimately affects sperm motility.Researchers believe that VSP is responsible for the polarization distribution of PIP2 in the flagella.Then, PIP2 activates potassium ion channels, which indirectly leads to local influx of calcium ions, thereby enhancing exercise capacity.In sperm lacking VSP, scattered PIP2 causes excessive influx of calcium ions, which reduces the flexibility of flagella and affects athletic ability.The above content is only authorized by 39Health.com for exclusive use, please do not reprint without authorization of the copyright party.

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INFERTILITY

At what age do men’s “functions” begin to decline?

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Some people say that a 20-year-old man loves to fall in love, and a 40-year-old man loves to love.Many men and women often care about and perplex this question: How often do husbands and wives live a life that is appropriate?Xiao Xu, 35, has been married to his wife for 5 years. His husband and wife have always lived in harmony. His daughter-in-law often complains that he is useless in intercourse.”Too tired! I used to do it once every two weeks, but now my wife complains a lot, and I try to do it once a week, but really, I can’t help it. I can’t help it.” Faced with his wife’s voicing, Xiao Xu couldn’t help it.Xiao Xu’s wife has also repeatedly advised him to go to the hospital for examination, but he always refuses.”If people don’t know if it’s okay, then what else can I do? Going to the hospital for consultation is to disclose privacy to the public, which is an insult to me personally.” Xiao Xu’s attitude was firm.”So, how do you judge whether you can or not?” In response to this problem, Xiaojiu today invited Chen Xiangfeng, deputy chief physician of the Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, and head of Shanghai Human Sperm Bank.Doctor, let him make scientific and detailed answers for everyone.How to judge if you can’t help it?In recent years, the problem of infertility has become increasingly prominent. The World Health Organization (WHO) has pointed out that infertility has become a global public health problem. Multiple data also show that the infertility rate is about 15%.That is, one in every 6-7 couples is facing fertility issues.There are many reasons for infertility, and men need to bear half the responsibility, because the abnormal quality of men’s sperm has become more and more significant.In 2017, the EAU guidelines proposed that about 50% of childless couples found factors related to male infertility, accompanied by abnormal semen parameters.Sometimes, when facing men’s problems, we need to take them seriously, and facing men who are unwilling to go to the hospital, they also need to give their most scientific advice.Take the case of “inadequate power” as an example. So, what frequency is appropriate?Is 35-year-old Xiaoxu abnormal once every two weeks or once a week?Frequency formula In fact, there is a formula for this problem that can tell everyone: multiply the ten digits of your age by 9 and the resulting tens digit is the number of days that a sex cycle lasts, and the single digits are the due frequency..For example: · 30-year-old person, his frequency should be “3 × 9 = 27”, that is, it is healthy to have married life 7 times in 20 days, that is, about once every 3 days; · frequency of people in their 40sShould be 4 × 9 = 36 ”, that is, there should be 6 times of husband and wife life in 30 days, about once every 5 days; · 50s people are“ 5 × 9 = 45 ”, that is, 5 times of husband and wife life in 40 days, about everyOnce every 8 days. If the frequency is not reached, it may be sick! Men, if your husband and wife are not living so frequently, then, consider that you may have a male disease and erectile dysfunction (hereinafter referred to as “ED”) Is one of them. A questionnaire survey of 2,226 men over 20 years of age in Beijing, Chongqing and Guangzhou showed that among men under 30 in China, the incidence of ED was 15.6%, and China was 40 and overAmong men, the incidence of ED is 40.2%. It is worth mentioning that age is the first influencing factor for erectile function. With increasing age, male androgen secretion is also declining, and when androgen is significantly lower than normalAfter the index, men tend to have weakness, lack of energy, and erectionThe ability to decrease and other symptoms, which is also called “late onset hypogonadism”, is commonly referred to as male menopause. However, we also found that stress and irregular lifestyles have become one of the important reasons for male ED. So, the currentYoung people, you are all overdrafting your physical health, you need to be careful! Three tricks teach you correct self-identification at a young age, and some people are really ashamed and embarrassed. So in the end, for those who are unwillingFrom the perspective of health, young men who go to the hospital, we provide three levels to help everyone self-examine the X function: the first level: see if they have Chen Bo (in the morning, usually get up), and night out (A priming occurs in the middle of the night) or a filling priming (the bladder is full of urine, and urine and priming will appear). If there is a priming, then enter the second pass. Second pass: When you start, look at the headThe direction of the head is related to the hardness of the ridge.If you are in a standing position, supine position, lateral position, or sitting position, and your head is pointing or leaning towards your own head position when it is in a raised position, then the hardness of the raised position is good. If the hardness of the raised position is perpendicular to the body torso, the hardnessIt is also normal; if the head is in the direction of his footsteps, the hardness is relatively poor..

The third hurdle: Observe Bo Qi’s maintenance time.Generally speaking, Boqi can last for three or five minutes, or even longer. The longer the duration, the better.However, if the drug can be used for a long time, then this situation should be a different matter.What level are you at now?* Reproduction is prohibited without authorization

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INFERTILITY

The unmarried female “frozen eggs” have not been released. The provincial health and health committee is conducting law enforcement inspections on the hospitals involved.

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Yesterday, there were media and online reports that “unmarried women’s frozen eggs” were frozen in Han’s low-key, Wuhan Tongji Reproductive Medicine Specialist Hospital received the first healthy unmarried female frozen egg pass in China.” Yesterday afternoon, the provincial health and health committee stressed: unmarriedFemale “frozen eggs” have not been released.Hu Rong, director of the Women’s and Children’s Health Department of the Provincial Health and Health Commission, said that in the course of daily supervision, the Provincial Health and Health Commission requires medical institutions with human-assisted reproductive technology qualifications to carry out medical services in accordance with the law and to prevent violations of laws and regulations.The Reproductive Medicine Center of Tongji Medical College of Huazhong University of Science and Technology, which is involved in media reports, is a non-profit enterprise integrating scientific research, teaching and clinical application. Hu Rong explained that the Provincial Health and Health Commission approved the establishment of the fertility preservation in Hubei Province.The center is to support them in carrying out research and promotion of reproductive medicine and is not a license.In response to the relevant activities of the center mentioned in the media reports, the Provincial Health and Health Commission has organized the health supervision department to conduct law enforcement inspections on the center yesterday, seriously investigate and punish violations of laws and regulations, and publish the investigation results according to law.In response to the egg freezing technology that everyone cares about, the director of the Provincial Medical Association Reproductive Medicine Branch, Mr. Yan Lei explained that the assisted reproductive technology service organization with in vitro fertilization-embryo transfer and other related technical qualifications can carry out this technology according to the law.However, assisted reproductive technology for unmarried or single women must be prohibited under any circumstances.What are the hazards of healthy women taking eggs?靳Ra introduced to carry out fertility preservation, mainly for young patients with malignant tumors or other serious diseases, before the chemotherapy or radiotherapy, egg, embryo or ovarian tissue cryopreservation.This technique requires an overdose of ovulation-promoting medications and an egg-taking procedure, an invasive, traumatic technique that can even cause serious complications.Therefore, unmarried, single women without any medical indications, egg freezing not only has the risk of causing harm to the body, but also seriously violates relevant national laws, regulations, policies, and ethical principles. , please do not reprint without the authorization of the copyright owner.

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INFERTILITY

How was the IVF born?

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In China, most families want to have a baby, let the family continue… and polluted air, vegetables and fruits containing pesticides, and increasing work pressure, it is not easy to have children. They all say that “no filial piety has three, no later is big”, but in modern society, it is really too difficult to truly achieve “no back”. Why is it getting harder and harder to get pregnant, and everyone doesn’t have to worry about “no after”? Because modern medicine is constantly evolving, we already have many ways to help people get pregnant. There are very few couples who really can’t have children. Among them, IVF is an important auxiliary reproductive means. Although test-tube babies often hear, have you ever wondered how the IVF was born? Let’s take a look at it together~ Secret! The whole process of birth of IVF First need to declare: IVF, not a child who grew up in a test tube, test-tube baby is just a common name, because in the past scientific research, more test tubes. When the sperm and the egg cannot meet in the body, the doctor takes the egg and the sperm by medical means, puts it in a petri dish, lets them meet in vitro, forms a fertilized egg, and cultures the fertilized egg into an embryo, and then puts the embryo into the womb. , it’s done. It’s simple to say, but in practice, there are still many steps. Let’s take a closer look at how the first generation of IVF was carried out (in fact, there are also 2nd and 3rd generations, first introduce the 1st generation technology). After a couple is determined to be a test-tube baby, the whole process needs to be completed in four steps: 1. ovulation induction; 2. egg retrieval; 3 in vitro fertilization; 4. embryo transfer 01 reduction regulation, normalization, female There is only one mature egg in a month, and in order to obtain more high quality embryos at a time, it is necessary to obtain a certain number of high quality eggs at a time. According to each person’s situation, the doctor will customize the personality scheme for ovulation. Stimulate the ovaries by applying a combination of drugs and drugs, while promoting the growth of a small number of small follicles so that a certain number of high quality eggs can be obtained. However, the process of ovulation induction is a big test for women, and mothers need to push the needle according to their own scheme. If the situation is not good, you need to continue to promote ovulation, or replace the program to promote ovulation. This foreign mother, in order to have a baby, made 7 test-tube babies in 4 years, and promoted the needles and the needles were tied 1616 needles. The baby born shortly lies quietly in the center of the picture, surrounded by the love of syringes and injections. 02 Take the egg and take the sperm. Take the egg: When the egg is mature, the doctor will take the egg, puncture the follicle to suck the egg, and immediately transfer the egg to the culture dish containing the embryo culture solution, and culture it in an incubator at 37 °C. Take the essence: Take the date of the sperm as the day of egg retrieval, and use the masturbation method to take the semen in the aseptic cup. 03 In vitro fertilization 4 to 5 hours after egg retrieval, the treated sperm and eggs are placed in the same dish and cultured for 18 hours. It can be understood that in the body, sperm and eggs meet at the fallopian tube, and in vitro, the culture dish simulates the fallopian tube environment, allowing sperm and eggs to naturally fertilize and form fertilized eggs. 04 Embryo Transfer The fertilized egg needs to be cultured in vitro for 2-3 days. The embryo at this time is about 8-16 cells. On the fifth day, the fertilized egg develops into a blastocyst. At this time, depending on the patient’s condition, choose 2-3 days of fresh embryos, or 3-5 days of blastocysts, and the extra embryos can be stored frozen. If the patient’s body is not recovered, the embryo needs to be frozen and the embryo resuscitation transplant is performed when the body recovers. Supplementation of hormones after embryo transfer Because it is artificially transplanted into the uterus, but the body parts have not been ready to “pregnancy”, so this time, we need to add progesterone to simulate the hormone levels of pregnancy. After 14 days of transplantation, the blood test hCG determines whether it is pregnant. If you are conceived, the child will grow up in the mother’s stomach like a natural pregnancy until the childbirth. Looking at the complete process, does it feel amazing? Even if sperm and eggs are not met in the body, people will work hard to meet them in vitro. Embryos formed in vitro, returning to the mother, can continue to grow until they become healthy fetuses.About IVF Everyone should not contradict or reject the IVF technology. It is a very common, medically assisted reproductive technology. Just like a broken leg requires plaster fixation, fever needs to eat antipyretics, eating fish is stuck and pulling out, just medical means. Whether it is a test-tube baby (in vitro fertilization embryo transfer), or natural conception, it is necessary to go through a mother’s hard life in October to be born safely, and there is no difference, it is a good baby of mom and dad! References: [1] Peng Jing, Lu Daru. Development and discussion of IVF technology [J]. Nature, 2010, 32 (6): 338-343.
[2] Deer group. Is IVF technically safe? [J]. Everyone’s Health, 2017, (22): 53. [3] Li Yuan, what is the mysterious test tube baby called IVF, the chief physician of the Reproductive Center of Beijing Chaoyang Hospital, the above content is only authorized for exclusive use by 39 Health Net, The copyright owner authorizes not to reprint.

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INFERTILITY

Infertility, don’t rush to blame the woman!

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After marriage, if the husband and wife are pregnant for many years, people usually find reasons from the woman, and think that infertility is the woman’s “pot.” But in fact, children can not be born, sometimes caused by the male, such as male sexual dysfunction, testicular spermatogenic dysfunction, abnormal sperm structure, stenosis obstruction, etc., are the culprit of couple infertility! According to research, infertility is not caused by unilateral factors in the family. The general female factor accounts for 40%-45%, the male party accounts for 30%-35%, and the common factors account for 20%. If the couple does not have signs of pregnancy for a long time after marriage, it is recommended to first find the reason from the man. This is mainly because the evaluation of male fertility is relatively simple. As long as the semen examination is carried out, preliminary judgment can be made. If it is determined that there is a problem with the man, then the woman can avoid unnecessary inspections, which saves the woman’s testing time and saves a fee. What are the reasons for male infertility? Generally speaking, the causes of male infertility are as follows: 1. Sexual dysfunction impotence, premature ejaculation, sexual desire disorder, ejaculation disorder (such as no ejaculation, delayed ejaculation, ejaculation weakness, retrograde ejaculation, etc.) are all male. The scope of dysfunction. Sexual dysfunction can prevent male sperm from entering the female, leading to infertility.
2, testicular spermatogenic dysfunction Male sperm produced by the testis, if the male testicular spermatogenic function is abnormal, it often leads to less sperm, weak sperm, dead sperm or azoless, leading to infertility. In addition, testicular abnormalities usually include cryptorchidism, varicocele, etc., which need to go to the hospital for investigation.

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INFERTILITY

Infertility check, do you understand these precautions?

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If you have children at home, it is natural to add a touch of color to your life. Raising a child has never been easy, and some parents have even stuck in the “start line” and have not been able to have their own children for a long time. Both males and females may have infertility due to a variety of factors. Therefore, if a husband and wife have no results after long-term pregnancy, they must go to the hospital for infertility examination. What do couples need to pay attention to when performing infertility tests? Let’s take a look at it in detail! Infertility check, what should you pay attention to? (1) It is necessary to temporarily suspend the husband and wife life before the examination. Whether it is male or female, we should pay attention to temporarily suspending the husband and wife life within a few days before the infertility check. For the man, it is necessary to ensure that the quality of the sperm is not affected. Similarly, the woman should temporarily stop related activities and maintain a good physical condition. (2) Do tubal angiography after menstruation. If you suspect that women are infertile due to tubal blockage, it is recommended to go to a regular hospital for fallopian tube angiography within 3~7 days after menstruation is clean. The accuracy of the test results is guaranteed, and if the test result is unclear, an additional uterine cavity check operation is required. (3) Both husband and wife should check

When it comes to infertility check, you need to pay attention to this problem. There is no doubt that infertility may occur in both men and women. Therefore, if it is really difficult to conceive after marriage, this time should not be the man or the woman to do the infertility project alone, but the husband and wife should work together to do the necessary inspection project test to help determine whether the man is the problem or The woman’s problem is ultimately targeted. Infertility check requires a lot of attention, and the most important thing to note is – don’t worry about it! If there is no result during pregnancy, then you must face up to the problem and go to the regular hospital for examination. Moin escaped and missed the opportunity he could have, affecting the birth plan. Neither the man nor the woman should have any ideological burden and learn to deal with it correctly.

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INFERTILITY

Can the “Loli” pockets in reality be able to bear children?

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Can a pocket person have a baby? Pocket people are still very common in our lives. Adults who are younger than 120cm in height are called pockets. The reason why there are small people is because they are congenitally lacking some growth hormones. These defects are not enough for them to develop normally to normal height. This resulted in a short stature and a short stature gene that is heritable. Can a pocket person have a baby? Let us know what to believe about this issue. Can a pocket person have a baby? The answer is yes, because the pocket people themselves are too short due to insufficient growth hormone secretion, but their development is mature, sexual organs and so on are mature, so the pocket person has the ability to bear. However, if a pocket person wants to have a baby, it also needs to have the following conditions: 1. The man’s testicles can produce normal fertile sperm. 2, the female ovary is also sound, can discharge normal eggs. 3, in the female ovulation period can go to the excessive sexual life of the birth, and can allow the female sperm and the male egg to form a normal fertilized egg in the female body to form a fertilized egg. 4. The female reproductive tract must be unblocked. 5, the environment in the uterus should be suitable for implantation of fertilized eggs, there can be no inflammation or other diseases. What issues should be paid attention to in the sex life of a small person? 1. Sexual life is strictly forbidden during menstruation: During the menstrual period, the cervix of the woman is open. At this time, it is very easy to cause infection in women, causing gynecological diseases in the genitals such as the uterus and attachments.

2. Prohibition of sexual intercourse after drinking: after drinking, especially after heavy drinking. Men may experience a series of conditions such as erectile dysfunction or premature ejaculation. These conditions can lead to disharmony, and the sperm produced at this time is also unhealthy and affects the next generation. 3, should pay attention to the number of sexual intercourse: the number of weekly sexual matters is recommended to be 3 to 4 times, if the physical condition itself is relatively poor, then the number of sexual intercourse should be reduced. The above is the answer to everyone about whether the pocket person can be pregnant. If you have doubts, you should understand it now!

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INFERTILITY

How do women improve fertility?

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Giving birth to a child is the right of choice for women. When it comes to having children, some women are out of love with children, and some women are willing to have “the crystallization of love” with their husbands. Today, late marriage and late child education has become a major trend. With the increase of age, women’s fertility will naturally have an impact. How to improve fertility in order to have a baby? Next, I will give you some suggestions for improving fertility. How to improve fertility? Suggestions for improving fertility: 1. Don’t lose weight casually. Many women in the life will choose to lose weight in order to make their body slim. In fact, this method is wrong. It is too heavy to be pregnant. If the weight is too light, it is also very Difficult to get pregnant. Obese women need to lose weight, but they do not need to lose weight. If the person’s weight is too light, it will cause the secretion of follicle stimulating hormone and luteinizing hormone in the pituitary gland, which will eventually reduce the number of eggs produced and cause infertility. 2, do not have sex during menstruation Although regular sexual life helps to conceive, but you can not live sex during menstruation, this is not right. During the menstrual period, the genital mucosa is in a state of injury. If it is sexually active at this time, the sperm will come into contact with the immune cells of the human body. After a long period of time, antibodies will be produced, and the sperm activity that enters the body is easily reduced. 3, less wearing tight clothing Many women want to be sexy, they will wear tight clothing, which will put a lot of pressure on the uterus and fallopian tubes. If this pressure is maintained for a long time, the chances of women suffering from endometriosis will increase, and the number of eggs with endometriosis will be relatively reduced, and the chance of infertility will increase. 4, usually do more exercise Women with pregnancy plans need to insist on doing half an hour of exercise every day, exercise can help maintain the activity of the egg, can enhance their physical fitness while helping themselves to improve fertility.

5, away from tobacco and alcohol Women can not smoke and drink, because cigarettes and wine have substances that harm eggs, but also cause ovarian aging. Women who smoke and drink alcohol for a long time will affect fertility, even if it is not for childbirth. For everyone’s health, it is necessary to stay away from tobacco and alcohol. How to improve fertility? Women who want to improve their fertility must pay more attention to the above five points. If you are still not pregnant for a long time, you need to go to the hospital infertility clinic to see a doctor. Finally, I wish you all the best, as soon as you wish, to become a “treasure mother.”

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INFERTILITY

How long have you not been pregnant with the doctor?

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China Women and Children Health Research Association Expert Group
Infertility refers to the normal sexual life of couples. No contraceptive measures have been taken for 1 year without successful pregnancy. Mainly divided into primary infertility and secondary infertility, the primary infertility is not contraceptive and never conceived, secondary infertility is once pregnant and then contraceptive for 1 year infertility. Therefore, a normal sexual life for 1 year, couples who do not take contraceptive measures and have no successful pregnancy should see a doctor. The causes of infertility are divided into male infertility and female infertility. Male factors that can be confirmed include hypogonadism, testicular abnormalities, and the like. Diagnostic female factors include ovulation dysfunction, fallopian tube injury, endometriosis, and cervical factors. In some cases, infertility can also be caused by sexual intercourse or other unknown causes. Basic infertility assessments include medical history, physical examination, semen analysis, menstrual history, laboratory tests, and assessment of fallopian tubes and uterus by hysterosalpingography, hysteroscopy, ultrasonography, and/or laparoscopy. Once the cause of the infertility is confirmed, medication or surgery, intrauterine insemination or IVF can be performed. ▲The above content is only authorized for exclusive use by 39 Health Network. Please do not reprint it without the authorization of the copyright owner.

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INFERTILITY

Infant leukemia has nothing to do with infertility treatment

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According to foreign reports, the largest research to date on whether there is a link between infant leukemia and pregnancy patterns suggests that children born through infertility treatment are less likely to develop infantile leukemia than those born through natural pregnancy. .
Dr. Rogan Spekto, of the University of Minnesota at the University of Minneapolis, said that children often develop leukemia before the age of one. Scientists believe that this disease is different from leukemia in older children. The United States has about 150 people each year. The child was diagnosed with infant leukemia. He said: “It is clear that when you have such a rare disease, it is difficult to find out the cause of the disease.”
An early study suggested that infertility treatment may be associated with this disease. To investigate this further, Spector and his colleagues studied 443 infants with leukemia and 324 healthy children. All children were diagnosed between 1996 and 2006.
The study found no relationship between infertility parents or infertility treatment and infant leukemia. They found that babies born to women who had to prematurely refrain from doing too much preparation were more likely to develop infantile leukemia than those born to women who had tried to get pregnant for nearly a year. Spector said that people should not believe this conclusion. “The more ways you cut down on data, the more unrealistic aspects you find.” He and his colleagues concluded that “we rule out infertility or treatment in this area can lead to risk of infantile leukemia.” Increased possibilities.”

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