1 Know that kinetic energy is thin, but people just don’t exercise!Do you want to lose weight?miss you!Then hurry up?Do not move!Many people feel that they are fat, but they are not willing to exercise. As a result, they are going further and further on the road of a quiet fat man… This is not your illusion!Recent research from the United States has found that people are indeed “speaking straight” in the matter of getting fat, while saying that they don’t want to be fat, they are getting fatter.However, even if you always feel that you are fat, people will not go to exercise.Unfortunately, the study also shows that only those who exercise can slim down!The study from JAMA Netw Open included data from the National Health and Nutrition Examination Survey (NHANES) for 1999-2016, involving a total of 48,000 participants in 9 surveys, of which 50.5% were women and 41.2% were 40-64 years old.The results showed that during the period 1999-2016, the number of people trying to lose weight in the United States increased from 34.3% to 42.2%.People often use diets to reduce their dietary intake, exercise, and drink plenty of water; people eat more fruits, vegetables, and salads, and they try to avoid sweets and sweets and change their eating habits.However, contrary to expectations, the American BMI has not only decreased with various attempts, but has also increased year by year, but it is really afraid of what comes!However, the research published in Obesity still points you to the road – want to be thin, or to exercise more!Research indicates that current exercise guidelines suggest that people combine aerobic exercise and muscle exercise to prevent obesity.The study included data from four public health surveys during the period 2011-2017. After analyzing the exercise and BMI information of more than 1.67 million people, it found that it met the weekly aerobic exercise time of more than 150 minutes and the US week 2 or more muscle exercise.The risk of obesity in the population is low.If you can exercise, grade 1 or above obesity (APR 0.54, 95% CI 0.53-0.54), grade 2 or above obesity (0.32, 0.31-0.33), and grade 3 or above obesity (0.21, 0.20-0.21) willSignificantly lower.Heavenly rewards, fat is the fatter you move!Although everyone wants to be thin, but those who are really slimming are those who are active, and others are getting fatter.Losing weight is not as simple as saying it can be slim down. It is necessary to consistently exercise enough and control the diet. After years of hard work, the weight scale pointer can be changed.2 These three actions hurt, you may have a broken vertebral body!Osteoporosis has become a common disease in the aging Chinese society. Do older people with low back pain need to do a magnetic resonance to rule out the fracture?I was afraid of over-examination, and I was afraid of missing the diagnosis. It was really difficult to decide.A recent study from the Daping Hospital in Chongqing, China, developed a three-action back pain induction test (BPIT) to predict the likelihood of a patient’s vertebral fracture by physical examination and to guide subsequent examinations.The BPIT examination developed in this study includes three actions of supine, turning over and getting up. If the patient is positive in any of the actions, it means that the patient has the possibility of vertebral fracture and should be further examined. At the same time,In patients with pain, the researchers also asked patients to quantify their pain severity using a self-reported numerical rating scale (NRS).The study prospectively included 510 patients with osteoporosis risk and back pain, and analyzed the relationship between this test positive and magnetic resonance detected vertebral fractures.The results showed that the sensitivity, specificity and accuracy of this test were 99.1%, 67.9% and 89.0%, respectively; the positive and negative predictive values were 86.6% and 97.4%, respectively.If the patient has pain during these three actions, then there is a 86.6% probability that a magnetic resonance will reveal the presence of a vertebral fracture; and if the three actions are completed, the patient is like a okay person, then there is97.4% likelihood that the patient is really okay.If the pain severity of the three movements of supine, turning over and getting up is more than 3 points, 0 points or 2 points, the corresponding diagnostic accuracy for vertebral fractures is also good, and the corresponding area (AUC) under the working characteristic curve can reach 0.898 respectively., 0.884 and 0.910.The researchers pointed out that this simple and easy examination can be used for stratification of patients with back pain at risk of osteoporosis.Negatives can avoid unnecessary magnetic resonance examinations, saving time and medical expenses; while positive ones should undergo magnetic resonance examination to confirm the presence of vertebral fractures and guide the next treatment and treatment.3 Chinese diabetes, genetic mutations are worth noting!A small proportion of people with diabetes are single-gene diabetics, but these patients are often misdiagnosed as type 1 or type 2 diabetes.About 1% of people diagnosed with type 1 diabetes in the European population actually have monogenic diabetes, while in Asia there are fewer people with type 1 diabetes, so the proportion of people who are misdiagnosed may be higher.Recent studies have found that the proportion of single-gene diabetic patients who are misdiagnosed in Chinese patients with type 1 diabetes may be six times that of Europeans!The study analyzed 82 Han patients diagnosed with type 1 diabetes. These patients were sequenced in exomes to find genes associated with monogenic diabetes.Although these patients were diagnosed with type 1 diabetes in the clinic, all three autoantibodies were negative.The researchers validated the patient’s disease-causing mutations in five ways to ensure that the results were true and reliable..
It was found that 18 of the 82 patients diagnosed with type 1 diabetes had mutations confirmed by five methods, and all of the mutations were pathogenic.The most common of these mutations is the HNF1A mutation associated with maturity onset diabetes of the young (MODY3) in young people, accounting for 6/18 cases.Another WFS1 mutation associated with Wolfram syndrome is the same.The researchers pointed out that because the negative rate of Chinese autoantibodies is 27.4%, and the mutation rate is 22%, it is estimated that about 6% of patients diagnosed with type 1 diabetes in clinical practice are actually single-gene diabetic patients.The researchers believe that patients with type 1 diabetes who are negative for autoantibodies in diabetes should be genetically sequenced to rule out the possibility of monogenic diabetes.Many of these patients may only require sulfonylurea or GLP-1 agonist treatment without the need for insulin injection; patients with GCK mutations may only need lifestyle intervention.The study also pointed out that diabetic patients with WFS1 mutations are not uncommon in China and should be given better and more appropriate treatment. , please do not reprint without the authorization of the copyright owner.