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How to care for patients with liver cancer in hot summer?

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Liver cancer has a high morbidity and mortality rate, and its morbidity is second only to lung cancer. Resection of liver cancer at an early stage can improve the cure rate.After a series of treatments, patients need to do a full range of care, especially in the hot summer, not rushing or drinking, or it will make the condition worse.How to care for patients with liver cancer in hot summer?1. When arranging a good diet, you must follow the Sanqing principle. One is coolness, which means eating more vegetables and fruits.One is light, the diet is mainly light, and the food is cooked through steaming, frying, stewing and cold salad.Another is tonic, choose beans or soy products rich in vegetable protein, low-fat poultry fish or lean meat, etc., to avoid eating hot and greasy food, to prevent hot dry injury.Summer air pollution is more serious, coupled with excessive exposure to ultraviolet rays, will increase free radicals in the body.In addition, summer consumption is large and malnutrition, the ability to scavenge free radicals will be reduced, may wish to drink 2 to 3 cups of green tea every day, green tea contains polyphenols, has a certain antioxidant effect and physiological activity, can protect the bodyCells to avoid damage by free radicals.2. Pay attention to personal hygiene. The high temperature and humid environment is suitable for the growth of pathogenic bacteria. The patients with liver cancer were originally very weak and consumed a lot. During the treatment, they lacked granulocytes, a lot of hormones were used, and the skin and mucous membranes were damaged.Obstruction due to obstruction and organ damage will increase the risk of infection and other complications, so you must pay attention to personal hygiene, take a shower, brush your teeth in the morning and evening, rinse your mouth after meals, pay attention to food hygiene, and not eat moldy and spoiled food.Keep air circulation in the living room and disinfect regularly.3. You can not go out in high temperature weather. Between 10 am and 4 pm is the strongest period of ultraviolet radiation. Try not to go out at this stage.In summer, the air conditioner is controlled at 26℃, and the temperature difference between indoor and outdoor should not exceed 7℃. After using the air conditioner continuously for two hours, it should be turned off, and the windows should be opened for ventilation.4. Drink plenty of water. The metabolism speeds up in summer, and it is easy to sweat. A lot of sweating will make the body lack of electrolytes and water. Cancer patients are prone to dehydration. Ensure that 1500~2500 ml of water is ingested every day. You can also drink light saline.Patients undergoing chemotherapy have a lot of sweating on their skin, and should pay attention to clean and dry skin, and change their wet clothes in time.To choose cotton loose and soft clothes, can reduce skin friction.Do not scrub the skin with iodine, soapy water or hot water, nor use alcohol-based ointments or lotions.Tips: Many cancer patients suffer from poor sleep during the hot summer months. It will reduce immunity and affect the treatment effect for a long time. Therefore, you must maintain mental relaxation, soak your feet before going to bed or listen to soothing music to improve sleep quality.

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CANCER

Tidulutide, a new option for acute graft-versus-host disease!

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GLP-2 treatment can overcome the deficiency of L cells, intestinal stem cells and Paneth cells caused by GVHD; the decrease in the number of L cells in gastrointestinal endocrine cells is related to the poor prognosis of patients with GVHD.Acute graft-versus-host disease (GVHD) is a life-threatening complication after allo-hematopoietic cell transplantation (allo-HCT).The current GVHD treatment plan is mainly targeted at the donor’s immune system. Recently, in the latest research in the “Blood” magazine, Norona et al. explored a method designed to protect and regenerate Paneth cells (PC) and intestinal stem cells (ISC) method.The researchers observed that acute GVHD reduced the intestinal GLP-2 levels in mice and patients with GVHD.In multiple mouse models, the use of GLP-2 agonist, teduglutide, treatment can reduce the incidence of new-onset acute GVHD and steroid-refractory GVHD without affecting graft anti-leukemia (GVL)The role.In mechanism, GLP-2 substitution promotes the regeneration of PC and ISC, thereby enhancing the production of antimicrobial peptides and causing changes in the microbiome.GLP-2 expands intestinal organoids and reduces the expression of apoptosis-related genes.In patients receiving allo-HCT, the low number of L cells and high serum GLP-2 levels in intestinal tissue biopsies are associated with high non-relapse mortality.In summary, this study suggests that L cells are a target of GVHD. GLP-2-based acute GVHD therapy can restore intestinal homeostasis by increasing ISC and PC without affecting GVL.Teduglutide is expected to become a new joint partner of GVHD immunosuppressive therapy, which can be verified by clinical trials.The above content is only authorized for exclusive use by 39Health.com.

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CANCER

What are the causes of lymphoma?

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When it comes to cancer, people tend to avoid it, and lymphoma is one of the common clinical tumor diseases. Although this type of cancer may be cured, it will also bring great health to the body.Injury, understanding the causes of lymphoma is conducive to the prevention and treatment of disease, so what are the causes of lymphoma?Let’s take a look at the causes of lymphoma.1. The physical cause of lymphoma.The occurrence of lymphoma is related to radiation factors.According to relevant research, the incidence of lymphoma has a great relationship with the dose of absorbed radiation. In addition, the incidence is also related to the age at the time of radiation. Studies have shown that for people who are frequently exposed to radiation before the age of 25The incidence of lymphoma is often much higher than other populations.2. Chemical causes of lymphoma.According to clinical practice, some chemicals are also toxic, which is one of the main causes of lymphoma. Experts said that alkylating agents, polycyclic aromatic hydrocarbon compounds, and aromatic amine compounds are relatively common chemical carcinogens.It is important to note that these chemical carcinogens have a great relationship with the cause of lymphoma.3. Immunological factors of lymphoma.According to experts, malignant lymphoma is a kind of malignant tumor of the immune system, and immunodeficiency is one of the important factors leading to the incidence of malignant lymphoma. Generally speaking, the human immune system is very powerful, and it has a very good immune surveillance function., Usually can play a good role in the body’s mutation or cancer cells can be eliminated.It should be noted that for immunodeficiency patients, infections are very likely to occur, especially viral infections.4. Genetic factors of lymphoma.The incidence of lymphomas is also closely related to genetic factors. According to relevant investigations, the incidence of lymphomas sometimes shows obvious family aggregation. For example, siblings can suffer from malignant lymphomas one after another or at the same time.In other words, the incidence of lymphoma has a great relationship with genetic factors.Knowing the causes of lymphoma is conducive to the prevention and treatment of disease. Everyone should actively avoid these factors from happening to themselves, and develop a good lifestyle, especially pay attention to not staying up late for a long time.

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CANCER

NATURE: “Universal” CAR T can also reverse aging

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The researchers tested the therapeutic concept of chimeric antigen receptor (CAR) T cells targeting senescent cells as an effective means of killing senescent cells.Cell senescence is characterized by stable cell cycle arrest and secretion characteristics to regulate the tissue microenvironment.Physiologically, aging, as a tumor suppression mechanism, can prevent the expansion of premalignant cells and has a beneficial effect in the wound healing response.Pathologically, the abnormal accumulation of senescent cells creates an inflammatory environment that leads to chronic tissue damage and contributes to diseases such as liver and lung fibrosis, arteriosclerosis, diabetes and osteoarthritis.Therefore, in mice, eliminating senescent cells from damaged tissues can help improve the symptoms of these pathologies and even promote longevity.Here, the researchers tested the therapeutic concept of chimeric antigen receptor (CAR) T cells targeting senescent cells as an effective means of killing senescent cells.First, the researchers determined that urokinase-type plasmid proactivator receptor (uPAR) 11 is a cell surface protein that is widely induced during aging, and showed that uPAR-specific CAR T cells can effectively ablate senescent cells in vitro and in vivo..CAR T cells targeting uPAR can prolong the survival of lung adenocarcinoma mice receiving senescence induction combined with drug therapy and restore tissue balance in mice with chemical or diet-induced liver fibrosis.These results establish the therapeutic potential of CAR T cells targeting senescent cells for aging-related diseases.The above content is only authorized for exclusive use by 39Health.com.

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High incidence of cancer, Shen Jian CA teaches you to scientifically prevent cancer!

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There are many rumors about anti-cancer and anti-cancer, there are many remedies, and some people even choose to resort to “metaphysics”.To prevent cancer, doctors usually recommend: maintain a healthy weight, exercise properly, and eat reasonably.For those without medical knowledge, it is difficult to grasp how to count as “healthy weight”, how to exercise to be considered “appropriate”, and how to be dieted as “reasonable”.Recently, the well-known journal CA published the “American Cancer Society’s Guidelines on Diet and Sports for Cancer Prevention”, which gives more detailed recommendations.Healthy weight: BMI is 18.5-24.9kg/m2 According to the definition of the World Health Organization, the healthy weight range of adults is the body mass index (BMI) of 18.5-24.9 kg/m2, and 25.0-29.9 kg/m2 is overweight, more than 30 kg/m2m2 is obese.The cause of overweight and obesity is often too much energy intake, and too little energy consumption, resulting in excess energy and too much fat.The guide recommends that you start from adolescents to control your weight within a healthy range, minimize the intake of high-sugar, high-fat foods, and avoid sitting for a long time.Appropriate exercise: At least 150 minutes of moderate-intensity exercise per week. Similar guidelines have been given in previous guides. For adults, 150-300 minutes of moderate-intensity exercise should be maintained per week, or 75-150 minutes of high-intensity sports.For teenagers, moderate-intensity exercise should be adhered to for at least one hour a day.Reasonable diet: balanced nutrition and low calories The Mediterranean diet is very popular because it has the characteristics of low calories, low sugar and rich in cellulose.A healthy diet needs to ensure that vitamins, minerals and other nutrients are sufficient.Use fish, poultry or beans as the main source of protein to reduce red meat intake.Eating more vegetables and fruits, from the perspective of nutrients and energy, increasing the proportion of vegetables and fruits intake is conducive to the prevention of cancer.Eating more beans and soy products can help supplement iron, zinc, potassium, folic acid, etc., eat less processed foods, and reduce the intake of sugary drinks.Smoking cessation and alcohol restriction: It is difficult to reverse the damage caused by smoking, and it is almost harmless. Many people already have the consciousness to quit smoking.And some people are willing to smoke, but can’t put down the wine.Although a small amount of alcohol is allowed in the Mediterranean diet, many studies have shown that even a small amount of people will cause irreversible damage to our bodies and increase the risk of cancer.It is also suggested in the guideline that it is best to avoid drinking altogether. If it cannot be avoided, women should not exceed 1 cup per day and men should not exceed 2 cups.The original content of 39Health.com (www.39.net) may not be reproduced without authorization, and offenders will be investigated.For content cooperation, please contact: 0000 or 0000

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How is breast cancer caused?

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Breast cancer has a certain morbidity rate among female patients, mainly due to some external factors that lead to the growth of malignant tumors in the female breast. Generally speaking, the treatment of breast cancer is very troublesome. If it is serious, it may need to be cut.Breast loss or death, therefore, on weekdays, we should understand the causes of breast cancer and avoid these causes as much as possible.What are the causes of breast cancer?1. Hormone changes The living environment has changed now. Many products exposed by women contain hormones, such as breast enhancement products, cosmetics, health care products, etc. These hormones have a certain impact on the body of women.There will definitely be an impact.2. Excessive pressure is no longer than before. Many women not only have to do housework but also go out to make money. Some women have even more pressure than boys. Excessive pressure will also have an adverse effect on the body because of excessive pressure.Large, directly affects your mood and sleep quality. Over a long period of time, it will make your immunity weak and eventually cause various diseases.3. Late marriage, late childbirth, and less breastfeeding. Remember that we learned that late birth and late childbirth, and fewer births, but for women, late marriage and late childbirth is a negative factor for the female body, especially if there is no breastfeeding, but will it causeWomen have not got accurate data on breasts, but they still let it happen and get married naturally at a suitable age.4. Many women with a history of breast enhancement are not born with very good stature. In order to change themselves and make themselves more beautiful, some women will choose breast enhancement, which will cost a lot of money.Choose to take breast enhancement drugs. Some breast enhancement drugs have too high levels of hormones. After taking them, it will increase the chance of women getting sick and it is very bad for the breasts.5. Hereditary breast cancer has a certain degree of heredity. Children born to women who have breast cancer have a much higher prevalence rate than children born normally without breast cancer. Therefore, genetics also cause breast cancerOne of the factors should be paid attention to.6. Bad living habits Many women have the habit of drinking alcohol and smoking, which will increase the risk of breast cancer, especially some women who are about to menopause. In order to avoid menopause, they will supplement themselves with estrogen, and often use oral emergency contraception for contraception.Medicine, etc., these bad habits are the treatment factors for breast cancer.The above are some of the reasons that cause women to suffer from breast cancer. Breast cancer has a great impact on women, and the condition has a certain degree of heredity. Therefore, we must pay attention to it and strengthen our daily exercise and exercise restraint.To reduce the incidence of breast cancer.

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Lancet: Aspirin reduces colon cancer risk in patients with Lynch syndrome

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Lynch syndrome is associated with an increased risk of many tumors, especially endometrial cancer.In 2011, researchers investigated the long-term effect of daily aspirin on tumor prevention in patients with Lynch syndrome. After an average follow-up of 55.7 months, the researchers recently announced the long-term evaluation of regular aspirin.In the CAPP2 trial, 861 Lynch syndrome patients (707 in Europe, 82%; 112 in Australia, 13%; 38 in Africa, 4%; 4 in the Americas, 1%) from 43 centers around the world were randomized to take daily600 mg aspirin or placebo.The primary end point is the diagnosis of colorectal cancer.A total of 861 patients with Lynch syndrome with an average age of 45 years participated in the study. Of these, 427 (50%) participants received aspirin therapy and 434 (50%) participants received placebo therapy.The average follow-up is 10 years, about 8500 person-years.Forty-two of the 427 subjects taking aspirin (9%) developed colorectal cancer, and 58 of the 434 subjects taking placebo (13%) developed colorectal cancer.Cox proportional hazard analysis showed that aspirin had a significantly lower risk compared to placebo (0.65), and negative binomial regression analysis showed a reduced risk (0.58).An analysis of 509 participants who received 2 years of intervention showed an HR of 0.56 and an incidence rate of 0.50.The rate of adverse events between the groups was not significant.Research supports that patients with Lynch syndrome take aspirin to prevent colorectal cancer.The above content is only authorized for exclusive use by 39Health.com.

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Every year more than 110,000 people in China cause cancer due to HPV!

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When it comes to HPV, the first reaction of most people is cervical cancer.HPV infection is a known important cause of cervical cancer. When the domestic HPV vaccine market gradually matured, recently, the famous journal “Cancer” published China’s HPV-related cancer data, studied from 2005 to 2015 for ten years, China’s newThe proportion of cancer cases that occur and die, related to HPV infection.Over 110,000 people cause cancer in a year, and the threat of HPV cannot be underestimated. According to research, there were about 110,000 new cancer cases nationwide in 2015 alone, and more than 36,000 cancer deaths can be attributed to HPV infection, accounting for the country respectively.3.4% and 1.8% of new cancer cases and deaths that year.This shows that HPV is a low-key big “boss”.Human papillomavirus (HPV) is a kind of virus that is susceptible to mucous membranes or epidermal squamous epithelium. The upper respiratory and digestive tract and anus, genitals and other organs are susceptible parts. HPV infection can cause various benign warts, which are seriousIt can also cause malignant tumors. Among them, cervical cancer is the most well-known. In addition, HPV infection can also cause penile cancer, vaginal cancer, vulvar cancer, oral cancer, laryngeal cancer, oropharyngeal cancer, and anal cancer.Pharmaceutical companies apply to expand the indications of HPV vaccine. Oropharyngeal cancer can also prevent timely vaccination of HPV vaccine. It helps reduce the risk of HPV infection and has a certain role in preventing cancers such as cervical cancer, oral cancer, anal cancer, and oropharyngeal cancer.Of course, in addition to the HPV vaccine, screening for related cancers is also important.Recently, as a manufacturer of the HPV vaccine Gardasil, Merck intends to apply for the FDA to expand its indications to prevent oropharyngeal cancer and other head and neck cancers caused by HPV types 16, 18, 31, 33, 45, 52, and 58.Merck Oriental said that after the HPV cervical cancer vaccine was introduced and gradually popularized, oropharyngeal cancer has gradually become the most common cancer associated with HPV in the United States, and the prevalence of men is five times that of women.For HPV, not only women should pay attention to prevention, men should also be vigilant, and HPV vaccine can also be given if conditions permit.The original content of 39Health.com (www.39.net) may not be reproduced without authorization, and offenders will be investigated.For content cooperation, please contact: 0000 or 0000

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BMC Cancer: Correlation between breast cancer and gut microflora disorder and breast cancer risk

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Breast cancer ranks first among women and is the second leading cause of death for this sex.In addition to genetic factors, the environment is also one of the causes of this disease, although the related factors are not yet clear.In the latter, the influence of microorganisms is one of them. Therefore, people have recently paid attention to the microbiota of the breast.We speculate that the risk of breast cancer may be related to the composition and function of the breast/intestinal microbiota, and exposure to environmental pollutants (endocrine disruptors, EDCs) may help to change these microbiota.We described a case-control clinical study to be conducted in women aged 25 to 70 years.The case will be a woman diagnosed with breast cancer (stage I and II) and undergoing surgical intervention.Women with cancer precursors or advanced tumor stages (metastasis), or who have received antibiotic therapy or any neoadjuvant therapy within 3 months of recruitment will be excluded.The control group will be women who have undergone surgical interventions for breast augmentation or reduction.Women with a history of oncology, gynecology, or endocrine, as well as women who have received antibiotic treatment within 3 months before recruitment will also be excluded.Blood, urine, breast tissue and stool samples will be collected.We will collect data on anthropometry, sociodemography, fertility history, tumor characteristics, and eating habits.Metabolomics studies will be performed on stool and breast tissue samples.In addition, metagenome studies will be conducted on stool and breast tissue samples to determine the population of viruses, fungi, bacteria and archaea in the microbiota.It will also quantify estrogen, estrogen metabolites, and EDCs in serum, urine, and breast tissue samples.This is the first time in the same study to assess the contribution of bacteria, archaea, viruses, and fungi, as well as changes in environmental pollutants to breast cancer risk.The results obtained will help elucidate risk factors, improve prognosis, and propose new intervention studies for this disease.The above content is only authorized for exclusive use by 39Health.com, please do not reprint without the authorization of the copyright party.

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Lancet oncol: Mortality of chest cancer after COVID-19 infection

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Early reports of cancer patients infected with COVID-19 suggest that compared with the general population, cancer patients have a higher mortality rate after infection with COVID-19.Considering the older age of patients with chest malignant tumors, smoking habits, combined cardiopulmonary diseases, and cancer treatment, such patients may be particularly susceptible to COVID-19 infection.This study aimed to study the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on malignant tumors of the chest.The inclusion criteria for this study were patients with suspected or confirmed COVID-19 breast malignant tumors (NSCLC, small cell lung cancer, mesothelioma, thymic epithelial tumors, and other pulmonary neuroendocrine tumors).From March 26 to April 12, 2020, a total of 200 patients with chest malignant tumors infected with COVID-19 were screened from 8 countries, with a median age of 68.0 (61.8-75.0) years, and 72% of them had ECOGPerformance status 0-1 points, 81% of patients have a history of smoking, another 76% of patients are non-small cell lung cancer, and 74% of patients were in cancer treatment when COVID-19 was diagnosed, and 57% of patients still had cancer treatmentIs in the first-line treatment stage.152 (76%) patients were hospitalized and 66 (33%) patients died.Of the 134 patients who met the ICU criteria, 13 (10%) were admitted to the ICU; the remaining 121 were admitted to the general hospital ward.Univariate analysis showed that they were older than 65 years (OR 1.88, 95% 1.00–3.62), had a history of smoking (4.24, 1.70–12.95), only received chemotherapy (2.54, 1.09–6.11), and any comorbidities (2.65, 1.09–7.46) Are related to increased risk of death.However, in multivariate analysis, only the history of smoking (OR 3.18, 95% CI 1.11-9.06) was associated with an increased risk of death.The data of this study shows that as the global pandemic of COVID-19 continues, patients with chest malignancies have a high mortality rate and a low ICU admission rate.Whether intensive care treatment can reduce mortality remains to be determined.The above content is only authorized for exclusive use by 39Health.com, please do not reprint without the authorization of the copyright party.

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