close

CANCER

CANCER

Frankly speaking, most people who do not get cancer easily have these 6 characteristics

59237.jpg

Cancer, a scary disease, is called “the king of all diseases.”Everyone hopes that he will be free of cancer all his life. In fact, if you think about it carefully, it may not be impossible.According to a survey by the National Cancer Registry, if the average lifespan of a 74-year-old is used, the probability of a person getting cancer in their lifetime is 22%.Although genetic mutation is the root cause of cancer, it is inevitable to avoid cancer, which is more determined by the acquired lifestyle and habits.There are 18 centenarians in Yongfu County, Guilin, Guangxi, China’s famous “hometown of longevity”. The reason why they are “immune” to cancer is mainly because they adhere to some good habits.Adhere to 6 good habits, you can also “immune” to cancer. 1. Work regularly. The British Scientific Cancer Research Center has studied more than 1,000 cancer patients from all over the world. It is found that more than 99% of patients often stay up late and go to bed after midnight.normal.Although many people know that staying up late is bad for your health, more people worry that staying up late will make your skin worse.In fact, staying up late has a deeper damage to the body-causing cancer.As early as 2007, the International Agency for Research on Cancer (IARC) has defined “staying up late” as a category 2A carcinogen, which belongs to the same category as the familiar red meat and hot drinks.On the one hand, staying up late will cause the circadian body clock to be disordered. Not only will the circadian clock disorder increase the risk of cancer, it will also make the cancer worse, the drug resistance is stronger, and the patient’s life span is shorter.Studies have found that nurses who often need night shifts have a higher probability of getting breast cancer than the general population; on the other hand, the human body will produce melatonin at night to protect the immune function, but the light will destroy its formation, and lack of melatoninIt is easy to increase the probability of leukemia, breast cancer, prostate cancer and other cancers.2. The harm to the body without drinking tobacco and alcohol is not only the liver, but also other organs.A large amount of research data shows that even drinking one or two liquors a day will increase the risk of various cancers.For example, the risk of oral cancer will increase by 82%, the probability of laryngeal cancer will increase by 43%, and the probability of esophageal cancer will increase by 39%. In addition, the risk of breast cancer, colon cancer and other cancers will also increase.Among the carcinogenic factors announced by WHO, smoking is ranked first.Even more frightening is that smoking will not only increase your own risk of cancer, but also your family’s risk of cancer.Some studies have found that people who have smoked for more than 20 years and smoked 20 cigarettes a day will have a 20-fold increased risk of lung cancer death. Family members who live with them will have a 6-fold higher risk of lung cancer than normal people!3. Healthy eating Eating leftovers for a long time will increase the risk of cancer of the digestive tract, because leftovers contain high levels of nitrite. If they are consumed for a long time, they will accumulate over time. When they reach a certain level, the digestive tract may be induced.cancer.Therefore, as far as possible, do not eat overnight meals, food control should be completed within 6 hours.Not only that, the chance of moldy leftovers will also increase, aflatoxin is a strong carcinogen, excessive intake will increase the risk of liver cancer.Eating while it is hot is also an unhealthy eating habit. Food is too hot and will burn the upper gastrointestinal mucosa. For a long time, it is easy to induce cancer. Therefore, the Chaoshan area that loves kung fu tea and the Taihangshan area that loves hot porridge are allHigh incidence area of ​​esophageal cancer and oral cancer.In addition, the harm of more meat and less vegetarian is not small.Unbalanced diet makes it easy to “eat fat”, and obesity has a close relationship with prostate cancer, breast cancer and other cancers.Not eating vegetables and fruits, and lack of vitamins also increase the risk of lung cancer, stomach cancer and other cancers.4. Emotional optimism Many people find that most elderly people with longevity have an optimistic mood and a positive attitude towards life.Modern medicine proves that when you are happy, a large amount of enzymes and hormones are secreted in the body, so that the blood flow and nerve cell excitement, and the liver’s metabolic activity reach the best state, and improve the body’s defense function.Someone once surveyed 109 long-lived elderly people and found that their characters are very cheerful and optimistic, which shows that optimism is an important factor to stay away from cancer and maintain a healthy and long life.5. Adhere to exercise. American research has proven that people who sit for a long time are more likely to develop colon cancer than those who exercise regularly. Men are also more likely to get prostate cancer.The reason why lack of exercise is easier to get cancer is because the body’s immune cells will decrease with the decrease of activity. If you do not exercise for a long time, the body’s immune cells will continue to decrease, and the probability of cancer will increase greatly.So, move away from cancer!Sixth, the weight is suitable for the German Cancer Research Center said that obesity has become one of the causes of cancer, and its risk is even equivalent to smoking!According to data released by Harvard University in the United States, the cancer risk of smoking is about 30%, while obesity has a cancer risk of about 10% for men and 15% to 20% for women.This shows that maintaining an appropriate weight is very important to prevent cancer!To be “immune” to cancer, we must first ensure a good lifestyle and habits. Of course, it does not mean that after maintaining the above several lifestyles and habits, we will not get cancer, but the risk of cancer will definitely be reduced.Many, it can be said that this is “insurance” of your own health, such a cheap and efficient cancer prevention method, why do you have no reason to do it?References:? 1. “If you don’t want to get cancer, you must change all 10 bad habits!”》. Popular Science China. 2018-04-302. Zhao Huanan. Emotional optimism and longevity [J]. Modern Health, 2006 (2): 17.

3. Shi Dongqing. Excessive weight becomes the main cause of cancer [J]. Frontiers of Medicine, 2012 (5): 58-58. It is forbidden to reprint the original content of 39 Health Network (www.39.net) without the author ’s permission without authorizationNo reprint, offenders will be investigated.For content cooperation, please contact: 0000 or 0000

read more
CANCER

When eating tofu, do n’t forget to match 3 kinds of food, the stomach is not blocked, but also calcium and iodine

39919.jpg

Today, Xiao Ai gave you a riddle: “born in the soil, fishing in the water, walking in the middle of the stone, becoming white and boneless, and people love to eat to get high nutrition.” If you don’t check the Internet, can you guess the answer??That’s right, the answer is tofu!Tofu is a common soy product, which is very popular with everyone. Recently, some people claimed that “Eating tofu every day can protect blood vessels, prevent cancer and anti-tumor”. Although Xiao Ai also likes tofu, it has anti-cancer effect, will it be too much?Overrated tofu?The nutritional value of tofu is undeniable, the nutritional value of tofu is indeed very high.Tofu is very rich in nutrients, and its calcium content is very high. For every 100 grams of tofu, the calcium content is as high as 140 to 160 mg, which is an ideal food for supplementing calcium.In addition, tofu also contains a lot of protein, soy isoflavones, iron, lecithin, and sugars. It is a low-calorie, low-fat but high-protein food.Chinese medicine believes that tofu is cold, can nourish qi and detoxify the body and the body. It is a heat-preserving food, and eating tofu can keep you slim.Tofu is also rich in phytoestrogens. Tofu is often eaten to prevent osteoporosis.The American Cancer Society said that soybean isoflavones in tofu have anti-cancer effects, and eating tofu can supplement soybean isoflavones is of great significance for cancer prevention.In addition, tofu contains a large amount of sterol and stigmasterol, these two substances have an important role in preventing breast cancer and prostate cancer.From the above information, tofu seems to prevent cancer?So, does tofu really have anti-cancer effect?Do n’t overestimate the nutritional value of tofu. People often say that eating meat is worse than eating tofu. This is not without scientific basis.A study by the National Cancer Center of Japan found that if you use tofu instead of meat, you can prolong lifespan, because the vegetable protein in tofu is associated with reduced mortality.According to data from more than 70,000 people in Japan, replacing 3% of red meat protein with plant protein reduces the risk of death by a quarter.Dr. Hu Bingchang of Harvard University also believes that the replacement of red meat and processed meat with tofu and other plant proteins is beneficial to health.The reason why tofu can prevent cancer is due to the isoflavone component.Soy isoflavones are widely found in legumes such as tofu, also known as phytoestrogens, which regulate the level of estrogen in women, that is, when the level of estrogen in the body decreases, it can play a roleIncrease the level of estrogen; when the level of estrogen in the body is high, it can play the role of reducing the level of estrogen.Epidemiological studies have found that there is a negative correlation between the intake of soy foods and the risk of breast cancer in women. That is to say, eating more tofu, soy milk and other bean foods can avoid breast cancer risk.Everyone agrees that tofu is a “good thing”, but for tofu, people think it is a kind of “junk food”, and some even call it carcinogenic.Tofu is not carcinogenic. People think that tofu is carcinogenic. In addition to its high salt content, some people think that the process of making tofu is made of mold, which is easy to cause cancer.However, compared to other preserved foods, the salt content of tofu is not too high. Moreover, during the production process, the nutrition of its raw material, soybean, is almost not lost. The mold used to make tofu is also a useful food.The fungus can decompose the hard-to-decompose substances in tofu to form the unique flavor of tofu. These fungi do not produce toxins, so there is no carcinogen.On the contrary, eating tofu in moderation is good for your health.Tofu milk is rich in protein, B vitamins, calcium and other substances, which can promote the catabolism of nutrients in the body and maintain health.What’s more, the unique flavor of tofu is also a rare delicacy.How to eat tofu healthy?As a common food, tofu has a variety of ways to eat, learn to mix correctly, but also make the nutrition richer.Tofu with radish can avoid suffering from indigestion.Because tofu is a plant protein, if you eat too much, it is easy to cause indigestion, and the digestion ability of radish is very strong. The combination of the two can not only absorb the nutrition of tofu, but also will not cause indigestion.Tofu with kelp, not only calcium, but also iodine.Kelp is also rich in iodine, which is very delicious when paired with soup.In addition, meat and eggs with tofu, can improve the utilization of protein in tofu, nutrition is higher than half.Because tofu is rich in protein, but lacks methionine, eating tofu alone, the protein usage rate will be very low, with meat and egg foods, can improve the utilization of protein.However, although tofu is rich in nutrients, there are three types of people who are not suitable for consumption: 1. The purine value of tofu is not low, patients with gout or those with high uric acid should pay attention to the intake; 2. Tofu is cold, stomach is cold, spleen deficiencyAnd those with kidney deficiency who often have spermatorrhea are not suitable for consumption; 3. Those who are prone to bloating and diarrhea should not consume excessive tofu.The tofu looks ordinary, but the hidden “knowledge” is so deep, do you also love tofu?References: 1. Tofu’s “golden partner” and edible taboos [J]. New Countryside (Heilongjiang), 2018, (27): 188.

2. Will tofu milk really cause cancer [J]. Staff Legal World, 2017, (21): 58. DOI: 10.3969 / j.issn.1008-9837.2017.21.029.3. Lu Huili. Eat tofu every dayAnti-cancer [J]. Family Health, 2012 (10): 29-29. Reprinting without authorisation is prohibited.

read more
CANCER

Five people died after fluorouracil chemotherapy!

no thumb

5-Fu (5-Fluorouracil, 5-fluorouracil) is a chemotherapeutic drug widely used in a variety of malignant tumors including head and neck tumors, breast tumors, and digestive tract tumors. In 2019, five cases occurred in France and the United Kingdom.Deaths caused by fluorouracil drugs after systemic chemotherapy.The cause of death in these patients is related to an enzyme related to the metabolism of the drug-DPD (dihydropyrimidine dehydrogenase, dihydropyrimidine dehydrogenase).DPD is the initial enzyme and rate-limiting enzyme of 5-Fu metabolism in the body. 80% -90% of 5-Fu is excreted in the liver after being metabolized by DPD to produce dihydrofluorouracil.And toxic reactions are closely related.The patients who died after chemotherapy as described above are suspected of having DPD enzyme deficiency in their bodies, which causes 5-Fu to accumulate in the body and eventually die due to drug toxicity.Afterwards, the families of these patients condemned the hospital for not testing the drug sensitivity before chemotherapy.These events also raise some questions: Should DPD enzyme testing be included in routine cancer chemotherapy practice?Today, let’s talk about these things about fluorouracil drugs and DPD.01 The latest announcement of the European Medicines Agency: DPD testing is required before chemotherapy with fluorouracil drugs. On March 13 this year, the European Medicines Agency (European medicines agency, EMA) issued a new announcement that cancer patients are receiving systemic fluorouracil(Including drugs that can produce fluorouracil after being metabolized in the body, such as capecitabine, tegio, etc.) Before chemotherapy drugs, DPD testing is required to ensure the safety and effectiveness of chemotherapy, which is conducive to the formulation of reasonable individualizationChemotherapy regimen, and for patients who need topical fluorouracil drugs, DPD testing is not necessary.The European Pharmacovigilance risk assessment committee (PRAC) pointed out that the level of individual DPD can be assessed by detecting the concentration of uracil in the blood or detecting mutations in DPD-related genes.For patients with DPD dysfunction, a reasonable reduction in the dose of fluorouracil chemotherapeutic drugs can effectively avoid serious and potentially life-threatening toxic effects, but specific standard guidelines for dose reduction have not been established.Regarding the drug fluorocytosine, which is a serious fungal infection, PRAC pointed out that although fluorocytosine can be metabolized in the body to produce fluorouracil, in order to avoid the delay of the disease, DPD testing before medication is not required.For patients who are known to have complete DPD dysfunction, it is necessary to avoid the use of flucytosine, and for patients who are known to have partial DPD dysfunction, if flucytosine is used, if there are serious toxic and side effects, the drug should be stopped in time.02 Whether DPD testing should be routinely conducted is still controversial. However, academics have different opinions on whether DPD testing is required before the use of fluorouracil chemotherapy drugs.Professor David Kerr of the Cancer and Hematology Center of Oxford University believes that patients who have been found to have obvious DPD defects in germline genetic testing should reduce the dose of chemotherapy drugs by 50% and follow up closely.Another British expert, Professor Karol Sikora of Buckingham Cancer Medical Center, opposed the routine DPD test. He believes that DPD polymorphism is not the only factor affecting drug sensitivity, and there are many other factors that check and balance each other.Even if there is evidence of genomics testing, it cannot be assumed that all abnormal DPD genes will cause high drug toxicity.Professor Karol Sikora pointed out that less than 10% of patients may have serious problems, and only about 1% of patients need treatment, dose reduction or other treatment measures (such as the use of antidote uridine triacetate) are neededYes, but there is no need to monitor all patients.In addition, some oncology experts in the United States also pointed out that there is no need for routine DPD testing.03 Is DPD functional defects common in Chinese patients?How to detect it?The incidence of DPD functional deficiencies varies among different races. In Caucasian races, the partial incidence of DPD function abnormalities is about 3% -5%, while in Asian races only 0-0.7%.A study on the peripheral blood DPD activity of the Han population in China found that peripheral blood DPD activity was negatively correlated with age and has nothing to do with gender; when the individual liver and kidney function abnormality, peripheral blood DPD activity decreased, pregnancy will cause increased DPD activity.Clinically, the efficacy and toxicity of pyrimidine chemotherapeutics can be predicted by measuring DPD activity, but it is difficult to objectively and accurately measure enzyme activity due to the influence of factors such as timing and treatment.At this time, genetic testing is the preferred testing method.DPYD is a gene encoding DPD, located on chromosome 1p22, with a total length of about 950kb, including a total of 23 exons.DPYD gene polymorphism includes duplication, deletion, insertion and single nucleotide polymorphism (SNP), among which SNP is the most common.A 2015 meta-analysis of DPYD mutations in Asia showed that the frequency of DPYD * 5 mutations in the Chinese population can reach more than 20%, and the frequency of DPYD * 9A mutations in the Chinese population is 7.04% without detectionA common DPYD * 2A mutation in the West.These detected polymorphic sites are all related to the chemotherapy toxicity of fluorouracil drugs.04 Clinical significance of DPD detection At present, Chinese scholars generally believe that the clinical significance of DPD detection before 5-Fu chemotherapy mainly includes the following points: ① Predict the sensitivity of 5-Fu chemotherapy: the activity of DPD in tumor tissue and 5-FU chemotherapyThe sensitivity is negatively correlated. The detection of DPD helps to judge the sensitivity of patients to 5-Fu chemotherapy; ②Predict the toxicity of 5-Fu chemotherapy: DPD detection helps to determine the dosage of medication and avoid the toxicity of chemotherapy caused by overdose; ③ as a basis for combination therapy: 5-Fu combined with DPD inhibitors (eg, Jimepyridine, 5-ethynyluracil) can improve the efficacy of chemotherapy, and some compound preparations (eg, Tigio) have achieved significant clinical efficacy;④ Chronic chemotherapy using circadian rhythm: DPD activity has circadian rhythm. Generally, it is highest at 1 am and lowest at 13 pm. Chemotherapy at a low DPD period can improve the efficacy;
⑤ Study the activity of DPD in different tissues: A related study found that the activity of DPD differs greatly between tumor tissues and normal tissues, and there is no correlation between the two.Too low DPD activity in normal tissues will cause 5-Fu to accumulate in the body and increase the toxicity of 5-Fu, while too high DPD activity in tumors will accelerate 5-Fu metabolism in the body and reduce the efficacy of chemotherapy.Regarding whether DPD testing should be routinely performed before systemic chemotherapy with fluorouracil drugs, there is no clear conclusion in the clinical diagnosis and treatment guidelines for various types of tumors in China, but patients with known DPD dysfunction should be treated with caution and follow-up to avoid serious chemotherapyThe occurrence of toxic side effects.The above content is only authorized for exclusive use by 39Health.com, please do not reprint without the authorization of the copyright party.

read more
CANCER

How long can I detect cancer?

43378.jpg

Old Li got esophageal cancer last year. During hospitalization, his wife Aunt Wang secretly asked the attending doctor: “Doctor, tell me the truth, how long can my old Li last?” The doctor patted Aunt Wang’s shoulder: “Aunt, youI ca n’t answer this question as a doctor, but I can tell you that the five-year survival rate of esophageal cancer is almost 30%, and Lao Li ’s condition is not too bad. We will do our best to rest assured. ”“ FiveYear? Are you saying that Lao Li can only live for 5 years? How should I tell Lao Li, my goodness! “Aunt Wang heard a doctor’s words and collapsed, after all,” survival “and” five years “are connectedTogether, it always feels like there is not much time left.Why should doctors use the five-year survival rate as an evaluation indicator?Five-year survival rate ≠ five-year five-year survival rate is a common concept in the medical world, but for cancer patients, this is a major problem related to the continuation of life.Because, the 5-year survival rate is often used as a measure of the effectiveness of cancer treatment.Patients who hear the 5-year survival rate often mistakenly believe that they can only live for 5 years, which is a large limit.In fact, the 5-year survival rate is only a medical statistic, it does not refer to specific patient cases.This indicator means that when the doctor tells the patient that the cancer at the lesion has been completely removed, the operation is quite successful. This is not yet a cure, it can only be said that the condition has been alleviated and controlled (stable).In layman’s terms, the five-year survival rate of cancer can be understood as: the proportion of patients who have survived for more than five years after a certain cancer has been treated.In fact, after the diagnosis of cancer, people who have lived for more than five years can be seen everywhere. The five-year survival rate of early breast cancer even exceeds 95%. You do n’t have to panic about the five-year survival rate.How long can I live with cancer?It is mainly related to 5 factors. 1. Tumor types Some experts once pointed out that the current 5-year survival rate of malignant tumors in China has increased by 10% compared with 10 years ago.Among them, the five-year survival rate of uterine cancer rose to 72.8%, thyroid cancer rose to 84.3%, cervical cancer rose to 59.8%, and esophageal cancer rose to 30.3%.The 5-year survival rate of esophageal cancer is even higher than that of some developed countries.The five-year survival rate of cancer varies depending on the type, but no matter what kind of cancer, the overall situation is optimistic.2. No matter what kind of cancer is the clinical pathology stage, the 5-year survival rate difference between TNM stage I and stage III is very obvious.In advanced cancer patients with metastasis, even if the metastatic site is surgically removed and chemotherapy is used, the long-term survival rate is not high.It can be seen that early detection, early diagnosis, and early treatment are extremely important to improve the efficacy.3. Whether radical resection can achieve radical resection is one of the key factors that determine the prognosis.Taking osteosarcoma as an example, the survival rate of patients undergoing radical amputation surgery at 3 and 5 years is significantly higher than that of patients undergoing limb salvage surgery.For patients, radical resection of tumor lesions is still necessary.4. A large number of clinical practice results of adjuvant chemotherapy confirmed that preoperative adjuvant chemotherapy can improve the resection rate of the primary tumor.In the postoperative adjuvant chemotherapy, gastric cancer is taken as an example. After radical resection of gastric cancer, the shed abdominal cancer cells form micrometastasis, which is one of the main risk factors for postoperative abdominal tumor recurrence and metastasis.It can be seen that postoperative adjuvant chemotherapy can improve the treatment effect and increase the 5-year survival rate.5. The older the patient, the lower the immunity and the worse the prognosis.In addition, cancer patients have a higher incidence of anxiety and depression negative emotions after surgery, and these negative emotions will cause patients to lose confidence in treatment and face treatment negatively, which is not conducive to prolonging the survival of patients.The five-year survival rate is just a reference, not decisive. If you take the five-year survival rate as an absolute, you can only say that you do not have enough knowledge about cancer.Doctors are not predictors. The five-year survival rate is just a statistical concept and does not necessarily refer to a patient ’s life and death outcome.The five-year survival rate is an estimate of the overall population, which is not decisive for individuals.Because of individual differences, even if the five-year survival rate is only 5% of pancreatic cancer, patients may survive more than five years after surgery (clinical cure), and anyone can become that 5%.And to be the 5%, it is important to do the following 3 points!Active cooperation with patients is a criterion that patients must follow.The treatment of cancer patients is relatively complicated, on the one hand, it requires medical staff to be skilled, on the other hand, it also requires close cooperation between patients and their families.Doctors, patients and their families are all comrades standing on the same front. Only by working together, trusting and cooperating with each other, can the therapeutic methods achieve its best results.After successful surgery and chemotherapy, it is not without worries. Cancer patients should still pay attention to regular review.Generally speaking, in the first year after surgery, it should be reviewed every three months; within 2 years after surgery, it should be reviewed every six months; more than 2 years after surgery, 1 or 2 detailed physical examinations and laboratory tests should be done every year;More than 5 years after surgery, you can consider to review every 1 year.Rehabilitation period is the key to winning the game. Patients receive standardized treatment and follow the doctor’s instructions to review on time. They should also pay attention to avoid the impact of specific high-risk factors in life.For example, breast cancer patients should pay attention to weight control, lung cancer patients should not smoke, patients with digestive system should not drink alcohol, and people with low immunity should not stay up late and fatigue.All in all, although cancer is terrible, it is still a disease that can be prevented and treated.The World Health Organization has long proposed that one-third of cancers can be completely prevented; one-third of cancers can be cured by early detection; one-third of cancers can prolong life, reduce pain, and improve quality of life through current medical methods..Improving the five-year survival rate, and even achieving long-term survival, is not a dream.References: [1] Shield of Ankang, Cancer Mo Neng [N]. 21st Century Business Herald, 2013.

[2] Deng Biyong, Qiu Bing, Deng Biqiang. Multivariate regression analysis of osteosarcoma survival rate [J]. Anhui Medicine, 2016, 06: 1127-1130. [3] Liao Yulin, Xu Hongtao, Zhou Yu. Nutritional status and psychologyThe influence of factors on the half-year survival rate and quality of life of patients with gastric cancer [J]. Modern Doctor of China, 2016, 10: 30-33. Reprinting without author authorization is prohibited

read more
CANCER

Can cancer patients take health supplements?

60149.jpg

Today, cancer is still an astoundingly discolored disease.Once you get cancer, people tend to be desperate.Even if patients have achieved clinical cure for their cancer, they will still pin their hopes on health products, hoping that health products can improve the body’s immune function and allow the cancer to completely disappear.However, cancer patients should not take health supplements blindly, otherwise there is a risk of recurrence.Abuse health products, watch out for cancer recurrence!At present, there are many health care products that “suppress cancer” in the market. Businesses have packaged their products very “professional” through various medical terms, under the guise of “suppressing cancer recurrence” and “reducing the side effects of radiotherapy and chemotherapy”.Attract high prices for cancer patients and their families.If the health care products are slightly effective, they will be exaggerated. If the health care products are ineffective, they will throw the pot on the patients. It is no wonder that they are terminally ill.The common people, who are eager to save their lives, are willing to spend a lot of money to buy these health products for their own health.In fact, the risk of abuse of health products is high, and patients cannot take it blindly.Recently, a study published in the American Journal of Clinical Oncology showed that cancer patients taking various dietary supplements such as antioxidants, iron supplements, and vitamin B12 may increase the risk of recurrence and death.In China, dietary supplements usually refer to health foods. Health foods are not medicines. Not only cannot they cure diseases, there is no evidence that they are effective against cancer.In addition, the sources of various health care preparations on the market are different, the prices are disparate, and the quality is not guaranteed. Cancer patients should be careful when purchasing or taking health care.Even if you want to eat, you must buy from regular channels, recognize the product brand, and it is best to buy and take under the guidance of a cancer specialist.How can cancer patients supplement nutrition?Generally speaking, if a cancer patient is in good health and has a normal appetite, there is no need to rely on health products.However, if your body is weak and your appetite is not good, you can go to the Oncology Nutrition Department for targeted diagnosis, evaluation and treatment to enhance the body’s spleen and stomach function and digestive ability, and promote nutrient absorption.For patients, usually in three meals a day, they must ensure balanced nutrition and diversified food types, including fish, meat, eggs, milk, beans and other foods. At the same time, they should eat more fresh vegetables and fruits.Light, you can use a wall breaker to break the food before cooking so that the patient can swallow and digest it.

read more
CANCER

Five “signals” or tips for early esophageal cancer!

32586.jpg

According to the National Cancer Statistics Report, esophageal cancer is one of the most common cancers in China.Unfortunately, many patients with esophageal cancer are found in the middle and advanced stages when they are discovered in the clinic, and the early detection rate is quite low. The main reason is that everyone’s health awareness is not strong enough, and they do not understand the early symptoms of esophageal cancer.If you want to detect cancer early and control its development in time, you need to know yourself and know its early symptoms!Early manifestations of esophageal cancer: 1. Pharyngeal sensation when swallowing food. The symptoms of esophageal cancer patients are mainly localized esophageal mucosal congestion, swelling, erosion, superficial ulcers and small plaque lesions. It is not very common when food passes through.Smooth, you will feel the discomfort of swallowing, this feeling is the same as choking during eating.2. There is always a foreign body in the esophagus. Patients with esophageal cancer always have some rice grains or vegetable fragments left on the esophagus wall when they eat. In this way, there will always be foreign bodies in the esophagus, parts with foreign body sensations and lesions of esophageal cancer.The locations are consistent.3. Food passes slowly and the esophageal caliber of patients with esophageal cancer becomes smaller, so that the food will feel stagnant when passing through. This feeling will only appear when eating, and will disappear after eating.Some serious patients have the same feeling of staying even after taking a sip of water.4. The throat is dry and urgent. Patients with esophageal cancer often feel that they are not very smooth when swallowing food, and have a slight pain, a little dry and tight feeling, especially if they eat some relatively dry and rough food.Sometimes, this feeling is particularly obvious.5. There is bloating and discomfort behind the sternum, and even patients with painful esophageal cancer will vaguely feel their chest discomfort, but they cannot find a specific location, and it is difficult to express clearly, that is, they feel that their body is not comfortable.In severe cases, there is pain behind the sternum when swallowing food.I hope that everyone can keep these 5 typical symptoms in mind and have to carefully observe your body in life. Once you find that you have one or more of the above symptoms, you need to seek medical diagnosis immediately without delay.39health.net (www.39.net) original content, can not be reproduced without authorization, offenders must be investigated.For content cooperation, please contact: 0000 or 0000

read more
CANCER

Family of 4 have had bowel cancer, and 3 have died!

58909.jpg

I was filming for 6 days a week, and gradually I couldn’t take it anymore. Julie Walters, “Mother Ron” in “Harry Potter”, was diagnosed with colorectal cancer. It is already in the third stage and must be treated with chemotherapy.Bright and beautiful stars can’t escape cancer, what about ordinary us?The 30-year-old Hangzhou guy, Xiao Jin, was lying on his back on the bed, staring desperately at the ceiling. “My grandma, father, and aunt all died of bowel cancer. I didn’t expect that I would get the disease 10 years earlier than them. Once I discovered that it was already in the middle and late stagesCancer cells have already metastasized to the lymph nodes ….. “Work 996 +” Meat and Less Vegetables “diet, the incidence of bowel cancer may overtake lung cancer. The incidence of colorectal cancer in China is rising at a rate of 5% per year.Both rates and deaths rank among the top five cancer lists in the city.In large cities such as Shanghai and Guangzhou, the incidence of bowel cancer is second only to lung cancer.Putting aside genetic factors, the dietary structure of three high and one low (high fat, high protein, high calories, and low dietary fiber) and sedentary habits are the keys to stimulating the rising incidence of colorectal cancer.It is also the leading cause of intestinal cancer among young people in their twenties and thirties.Take Xiaojin, for example, not only is he busy with work, the daily work rhythm is 996, there is little time to exercise, and the diet is a typical “carnivore”. He likes to eat fried and greasy food, and supper is standard every night.Some experts and scholars predict that if effective anti-cancer measures are not taken and development is allowed to continue, the incidence of colorectal cancer will sooner or later surpass lung cancer in the Chinese mainland, and will succeed the new “King of Cancer” throne.Three cases are precancerous lesions. The first colonoscopy colorectal cancer, which should be the first time in life at the age of 40, is also called colorectal cancer, including colon cancer and rectal cancer.Unlike other cancers, colorectal cancer is one of the few preventable and curable malignancies.The precancerous lesions are often relatively clear. Most bowel cancers slowly develop from benign lesions of the intestine. This process takes at least 10 years, or even 20 to 30 years.This gives us enough time to prevent bowel cancer.The following three cases are precancerous lesions of bowel cancer: precancerous lesions 1, adenoma-like polyps.Intestinal polyps are intestinal mucosal bulges, most of which are benign, but one of them is an adenoma, also known as an adenoma-like polyp.70% of bowel cancers originate from adenomas. The larger the adenomas, the higher the chance of canceration.Studies have shown that adenomas over 2.5 cm in diameter increase the risk of canceration to 12%.Precancerous lesions 2, ulcerative colitis.This is an unexplained chronic inflammation of the rectum and colon. The main symptoms are diarrhea, mucus, pus, blood, stools, abdominal pain, and post-emergency.According to statistics, about 3% -5% of ulcerative colitis will cause colon cancer.Precancerous lesions 3. Familial polyposis (also known as familial adenomatous polyposis).This is an autosomal dominant hereditary disease that, if left untreated, can be altered by 100% before its 50th birthday.Once cancerous, it is often a multiple, polycentric cancer.As long as the precancerous lesions are removed, the occurrence of colorectal cancer can be effectively prevented, and the mortality of colorectal cancer can be significantly reduced.These cancerous lesions are mostly found through regular inspections. Digital anal examination, fecal occult blood examination, and colonoscopy are commonly used inspection methods.Bowel cancer experts caution that if you have never had a colonoscopy, it is necessary to do it once you are 40 years old.For those over 40 years of age with early symptoms (blood stools, increased defecation, bowel-like stools, abdominal pain, anemia, etc.), gastroscopy is recommended once a year.References: 1. Colorectal cancer or become a new “cancer king”, delicious lazy is the key!Medical Forum Network. October 17, 2019 2. A family of 4 has colorectal cancer, 3 have died!The youngest is only 30 years old. Zhejiang Online Health Network. July 5, 2019 3. “Harry Potter” “Mother Ron” passed on tears in her bowel cancer husband. Guangming.com February 22, 2020 4Comic colorectal cancer. Edited by Wan Desen. People’s Health Publishing House 39 Health Network (www.39.net) original content, can not be reproduced without authorization, offenders must be investigated.For content cooperation, please contact: 0000 or 0000

read more
CANCER

Don’t be too happy about weight loss!

44501.jpg

In a gourmet country, taste and risk often coexist.Kung Fu tea, hot pot, betel nut and other Chinese special diets have been shown to increase the risk of esophageal, gastric and oral cancers.And when there is already a certain risky eating pattern, the risk of gastric cancer almost doubles when it comes to the bad eating habits of contemporary people who “don’t take the next meal”!The incidence of gastric cancer has become younger in recent years. In addition to the poor living habits, young people also lack a certain awareness of anti-cancer. They often think that they are young and strong and will not get a major illness such as cancer.It also defaults to gastritis caused by poor diet and is rarely associated with gastric cancer.In fact, chronic gastritis is prolonged and there is a high risk of gastric cancer. In addition, patients who have missed early diagnosis and treatment in the clinic are often mistaken for the “signal” of gastric cancer for gastritis.So, what are the symptoms of early gastric cancer?(1) Loss of appetite and body wasting There is no specific symptom in the early stage of gastric cancer. Patients may show inexplicable symptoms of appetite at the beginning, and their weight is also dropping sharply, and the body will quickly lose weight. This isEarly symptoms of gastric cancer that are common but lack specificity in the clinic.At the same time, patients will experience abdominal distension and belching after eating, which will make patients suspect that they are only caused by indigestion.However, if the related symptoms do not improve after conditioning, you must go to the hospital for treatment in time.(2) Upper abdominal fullness and discomfort Generally speaking, patients with upper abdominal fullness and discomfort usually experience a large amount of food after eating. Even if the patient eats only a small amount of food, the upper abdomen still feels full, which leads to the patient’s reluctance to eat more, And the full position is below the navel or to the right.(3) Patients with nausea and vomiting will not only feel full and discomfort after eating, but also accompanied by mild nausea and vomiting, and patients with severe conditions may experience swallowing difficulties, food reflux, etc. as the disease progressesIt is also possible that the problem of vomiting due to pyloric obstruction may further develop.When the disease progresses to this step, it means that it is already serious. At this time, you can no longer act arbitrarily. You must get rid of everything and go to the hospital for treatment in time.Gastric cancer often has no specific symptoms in the early stages, so everyone must pay more attention to their bodies in daily life. Once abnormal conditions occur, they must be paid attention in time, and timely examination and treatment should be given.Do n’t feel that you ca n’t take time out from your busy work. In fact, illness does not “pity” us. Only by paying full attention to changes in the body and discovering abnormalities in time can we avoid greater risks and damage. Do n’t drag small problems into big problems.

read more
CANCER

How to choose chemotherapy for elderly non-squamous non-small cell lung cancer over 75 years old?

no thumb

In recent years, the number of elderly people diagnosed with lung cancer has gradually increased, and more than a third of newly diagnosed cases are patients over 75 years of age. Although targeted therapy and immunotherapy have increased multiple treatment options for non-small cell lung cancer (NSCLC),However, chemotherapy is still the backbone of atypical driving gene mutation patients or targeted therapy and immunotherapy resistant or intolerant patients. It is expected that the number of elderly patients will further increase, and it is important to choose more effective treatment options.Recently, “JAMA Oncology” magazine published the first phase III clinical study of elderly non-squamous NSCLC patients over 75 years of age, details are as follows: Research background With pemetrexed in non-squamous non-small cell lung cancer (NSCLC) patientsIt has shown good efficacy and good tolerability. The efficacy of pemetrexed combined with carboplatin in elderly non-squamous NSCLC has also received increasing attention. In a single-arm phase II study, carboplatin combined with carboplatinSequential memetrexed pemetrexed maintenance therapy has shown good efficacy in non-squamous NSCLC patients over the age of 75 (median OS 20.5 months, median PFS 5.7 months).The researchers immediately launched a phase III JCOG1210 / WJOG7813L non-inferiority study to evaluate carboplatin combined with pemetrexed sequential pemetrexed maintenance therapy versus docetaxel single-agent chemotherapy for primary treatment, age 75 and olderEfficacy and safety of patients with advanced non-squamous NSCLC.Methodology This is an open-label, multicenter, non-inferiority phase III clinical study conducted at 79 institutions in Japan.The study included patients with advanced non-squamous non-small cell lung cancer who were initially treated with cytotoxic chemotherapy aged 75 years and older, with an ECOG score of 0 or 1.Patients were randomly assigned to receive docetaxel (60mg / m2, every three weeks) or carboplatin + pemetrexed (500mg / m2) (every three weeks) in a 1: 1 ratio and received sequential pemetrexed for 3 weeks.Stratification factors include clinical disease stage, gender, and EGFR mutation status.The primary endpoint was OS in the intention-to-treat population.Results: From August 12, 2013 to February 20, 2017, 433 patients were randomly assigned to receive docetaxel or carboplatin + pemetrexed. The baseline characteristics and disease-related characteristics of the two treatment groups were balanced.97% of patients had EGFR gene testing, of which 21.9% had EGFR-sensitive mutations. All of these patients had received at least one EGFR TKI therapy before. Finally, efficacy and safety analysis was performed on 428 patients.The median treatment cycles of the docetaxel group and the carboplatin + pemetrexed group were 4 and 6, respectively.The dose reduction occurred in 61.3% and 22.7% of patients in the two groups. The main reason for the dose reduction in the docetaxel group was the decrease in neutrophil counts, while the most common reason for the dose reduction in the carboplatin + pemetrexed group wasDecreased neutrophil or platelet count.Each of 214 patients received these two treatments. The main reason for discontinuation of treatment was disease progression. The two groups had 58.9% and 60.7%, followed by adverse events, 23.4% and 26.2%, respectively. They were rejected due to toxic reactions.The patients treated were 13.6% and 9.8%, respectively.The median follow-up time was 27.5 months, 328 (77.0%) and 161 (74.5%) patients died in the two groups, the OS HR in the intentional population was 0.85, and the median OS in the two groups was 15.5 months and 18.7.In March, the two-year OS rate was 33.4% and 40.0%, respectively.Compared with the docetaxel group, the median PFS of the carboplatin-pemetrexed group was significantly longer. The median PFS of the two groups was 6.4 months and 4.3 months (HR = 0.739, P <0.001).The group analysis results were consistent with the intentional population.Analysis conclusion Although there is no consensus on the definition of the elderly, previous Phase III studies of elderly patients with advanced NSCLC have included patients over 70 years of age, and platinum-based chemotherapy is usually 70-74 years old, suitable organ function and PSFirst-line treatment regimen for 0 or 1 patients.This study is the first phase III study in patients with advanced non-squamous NSCLC aged 75 years and over. The results show that carboplatin combined with pemetrexed sequential pemetrexed maintenance treatment can be advanced non-squamous 75 years and older.NSCLC patients have significant benefits and are well tolerated, so this combination therapy can be a standard treatment option for such patients.The above content is only authorized for exclusive use by 39Health.com, please do not reprint without the authorization of the copyright party.

read more
CANCER

The risk of ifosfamide-induced encephalopathy cannot be ignored!

no thumb

The European Medicines Agency is reviewing: Are ifosfamide ready-made solutions more encephalopathy risk than powders?As everyone knows, ifosfamide is a broad-spectrum anticancer drug, and it has a risk of inducing encephalopathy in clinical application, and it is also reflected in drug information.It is reported that the incidence of ifosfamide-induced encephalopathy is about 10% to 20%.The black box warning reminds that the confusion and coma caused by the toxicity of the nervous system are related to the treatment. If it occurs, please stop the treatment.So, the question now is: Is the risk of encephalopathy caused by ifosfamide ready-made solution greater than that of powder (used as a solution)?The European Medicines Agency (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) is currently reviewing this issue.PRAC has begun analysis and evaluation of some ifosfamide-containing drugs.Previous research has shown that ifosfamide ready-made solutions have a significantly higher risk of encephalopathy than powders.In 2016, a survey in France showed that the incidence of encephalopathy in ready-made solutions is three to four times that of powders.Based on the analysis, France has taken precautionary measures and shortened the shelf life of ready-made solutions to 7 months.In 2019, a case-control study showed that liquid formulations had a higher risk of residual encephalopathy compared with ifosfamide lyophilized powder formulations [adjusted odds ratio (OR) of 1.91]; a retrospective study showed that liquid formulationsThe incidence of encephalopathy was significantly higher in the preparation group than in the lyophilized powder preparation group (10.2% vs 1.9%).Based on this, EMA states that it is currently assessing available data on the risk of encephalopathy caused by ifosfamide ready-to-use solutions or concentrates, and then advises whether marketing authorizations for these products are maintained, changed, suspended or revoked.From the following points, the most common encephalopathy symptoms induced by ifosfamide encephalopathy treatment are: drowsiness, insanity, depressive psychosis, and hallucinations.Other rare symptoms are dizziness, loss of orientation, and neurological dysfunction.Occasionally, seizures and fatal coma are reported.Risk factors for ifosfamide encephalopathy include: poor general condition, impaired renal function (creatinine> 1.5 mg / dl), previously receiving nephrotoxic drugs (such as cisplatin), and post-renal obstruction (such as tumors of the renal pelvis).Other possible risk factors are old age, alcoholism, decreased plasma albumin and bicarbonate levels, liver insufficiency, or concurrently receiving high doses of antiemetic drugs.How to treat and treat ifosfamide encephalopathy?Under normal circumstances, encephalopathy symptoms are reversible.Once the patient reports symptoms of encephalopathy such as drowsiness and hallucinations, the use of ifosfamide should be stopped in time, and methylene blue should be administered intravenously until the symptoms disappear.Other preventive measures include infusion of albumin, glucose and vitamin B1.From the following aspects, quickly understand the basic information of ifosfamide. Ifosfamide is an alkylating agent and a synthetic analog of cyclophosphamide. It has been approved by the US FDA for marketing since 1988. It is often used in combination with other anticancer drugs.For the treatment of malignant lymphoma and other solid tumors.In Germany and France, ifosfamide is available in off-the-shelf solution (a concentrated solution) and powder (ready-to-use); however, ifosfamide powder is only available in most EU countries.In our country, the currently available ifosfamide is only powder.Efficacy and uses abroad Ifosfamide can be used in combination with other antitumor drugs for third-line treatment of germ cell testicular cancer.In addition, ifosfamide has been qualified as an “orphan drug” for the treatment of bone and soft tissue sarcomas, as well as “off-label use” for lung cancer, breast cancer, ovarian cancer, cervical cancer, pancreatic cancer, bladder cancer, gastric cancer, and non-Hodgkin’s lymphoma.In China, the indications for ifosfamide are: testicular cancer, ovarian cancer, breast cancer, sarcoma, malignant lymphoma, and lung cancer, etc .; the indications beyond the instructions are: neuroblastoma, childhood acute lymphoblastic leukemia.Medication precautions At the same time as ifosfamide administration, 4 hours and 8 hours after administration, mesna (usually 20% of the total daily amount of ifosfamide) is given to prevent hemorrhagic cystitis.Before treatment and 72 hours after treatment, a sufficient amount of water is recommended, and oral or intravenous infusion of> 2L of fluid daily to minimize the risk of hemorrhagic cystitis.During the administration, the total blood cell counts (CBCs) should be monitored.In addition, it should be noted that ifosfamide is contraindicated in patients with severe myelosuppression, allergy to ifosfamide, bilateral ureteral obstruction, and pregnant and lactating women.Adverse reactions The adverse reactions of ifosfamide include hematological toxicity (such as leukopenia), gastrointestinal reactions (such as nausea), urinary tract toxicity (such as hematuria), central nervous system toxicity (such as drowsiness), and so on.Adverse events with a incidence> 10% include: hair loss (83%), nausea (58%), vomiting (58%), leukopenia (50%), hematuria (46%), metabolic acidosis (31%),Thrombocytopenia (20%), central nervous system toxicity (12%), neurotoxicity (10% -20%).Adverse events with a incidence of 1% to 10% include: infection (8%) and kidney damage (6%)..
Adverse reactions Although there are only sporadic reports of ifosfamide-induced encephalopathy in China, they should not be ignored. Once they occur, treatment should be given in time. At the same time, those risk factors that may increase the occurrence of encephalopathy should be paid attention to and avoided or eliminated as far as possible.The above content is only authorized for exclusive use by 39Health.com, please do not reprint without the authorization of the copyright party.

read more