Order more coffee and less diabetes!

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Stay in shape and stay away from type 2 diabetes, high blood pressure, fatty liver, stroke, gout, gallstones, and death … 1 130,000 people in Shanghai study: Middle-aged well-being and elderly obesity are associated with an increased risk of various chronic diseases, includingType 2 diabetes, cardiovascular disease, stroke, hypertension, stroke, and more.In the past, we were poor. Without so many fat people, we naturally didn’t worry about obesity.However, the obesity rate of Chinese people has increased rapidly in just a few decades. The total number of obese people has surpassed that of the United States, ranking first in the world. It is necessary to evaluate the impact of obesity on people’s health in the Chinese population.Recent studies from Shanghai have confirmed the dangers of obesity.In short, it means getting middle-aged and getting old!The study was published on JAMA Network Open.The study included 74,941 women between the ages of 40-70 and 61,482 men between the ages of 40 and 74 from the Shanghai Women’s Health Study and the Shanghai Men’s Health Study, of which approximately 83,000 people hadWeight data at 20 and 40-59 years.The study analyzed the relationship between participants’ middle-aged well-being and subsequent illnesses and deaths.The study was recruited as early as 1996. The average age of women was 47.8 years, the average age of men was 49.6 years, and women were generally thinner. The study continued until 2018.It was found that the risk of death increased by about 10% for every 5 kg of blessings from young to middle-aged.Among them, among those who gained more than 20kg or BMI exceeded 23kg / m2, women’s increase was about 14% (HR 1.14, 95% CI 1.10-1.19), and the risk of death related to cardiovascular disease increased by 23% (1.23, 1.14-1.33)); Although the increase in the risk of death for every 10 kg of weight of men is less than that of women (1.09, 1.04-1.14), the risk of death related to cardiovascular disease increases even more (1.26, 1.16-1.38).At the same time, the risk of cancer increases.For women who gain more than 20kg or BMI of more than 23kg / m2, every 5kg of weight gain increases the risk of all cancers, obesity-related cancers, and liver cancer, especially postmenopausal breast cancer (2.20, 1.51-3.22)And uterine body cancer (2.75, 1.83-4.13) risk more than doubled; in men, a relationship between weight gain and increased risk of obesity-related cancers was found (1.34, 1.07-1.67), but lung cancer risk was reduced (0.58, 0.39-0.87).In addition, weight gain is also associated with an increased risk of type 2 diabetes, hypertension, fatty liver, stroke, gout, and gallstones. The risk of type 2 diabetes in women who weigh more than 20 kg can even reach 7.87 times that of normal-weight women (7.87, 6.91-8.97).Researchers point out that weight gain from early to mid adulthood is associated with an increased risk of disease incidence and later death, which is consistent with the results of previous studies.However, it has also been found in Chinese that in mid-adults with a BMI of 18.5-22.9 kg / m2, weight gain is still associated with an increased risk of type 2 diabetes, hypertension, ischemic stroke, fatty liver and gallstonesMen also have an increased risk of acute myocardial infarction, cholecystitis, and gout.Researchers believe that this may be related to Asians being more sensitive to insulin resistance, and obesity is more likely to lead to overexpression of hormones and adipokines, chronic inflammation and insulin resistance, leading to an increased risk of various chronic diseases in Chinese even if they are healthy.2 365 for mothers and babies: the prevalence of drug abuse during pregnancy, child obesity, childhood obesity, and high-energy foods are considered to be the main reasons for the increased incidence of type 2 diabetes in children, but the environmental risks of mothers during pregnancy cannot be ignored, such as air pollutionWe think that it is related to this.Maternal PM2.5 exposure during pregnancy may be associated with offspring adulthood of type 2 diabetes and increased risk of overweight / obesity in childhood.Recent studies from Mexico have further demonstrated that the harm of air pollution to offspring may begin when children are a few years old, and that offspring of women exposed to PM2.5 during pregnancy may have glucose metabolism disorders at the age of 4-6 years.The study was also recently published on JAMA Network Open.The study included information from 365 pairs of mothers and infants in the PROGRESS birth cohort study, of which 50.4% were girls.The study started with the mother’s pregnancy, and the children were followed up to about 7 years old.HbA1c levels were collected at the age of 4-5 and 6-7 years of age during the follow-up.Researchers define PM2.5 exposure during pregnancy as the level of PM2.5 exposure from 4 weeks before the last menstrual period to 12 weeks after delivery, and estimate it based on the satellite PM2.5 value of the home address of the pregnant woman during this period, based on the measured PM2.5 on the groundLevels, land use and meteorological conditions were calibrated.It was found that the average age of pregnant women was 27.87 years, the average BMI was 26.4 kg / m2, and the PM2.5 exposure level during pregnancy was about 22.4 μg / m3.Compared with pregnant women with PM2.5 exposure levels of 12 μg / m3 during pregnancy, offspring exposed to average levels of HbA1c increased by 0.25% (95% CI 0.004% to 0.50%) from 4-5 years to 6-7 years.The analysis results in girls found that this level of change was significant in girls, with an increase of 0.21% (0.10% to 0.32%), but not in boys (0.31%, -0.09% to 0.72%).Among them, 28-50.6 weeks after the last menstrual period seem to be the key period in which PM2.5 exposure affects the blood glucose levels of the offspring, while in girls this period is 11 weeks to the end of the last menstrual period.For girls, exposures at weeks 16-32.7 are associated with lower levels of HbA1c at the age of 4-5 (? 0.72%,? 1.31% to? 0.13%), while in boys the window period begins to 32.7Week (? 0.98%,? 1.70% ~? 0.26%).Researchers point out that prenatal and perinatal PM2.5 exposure is associated with changes in HbA1c levels in early childhood and may indicate abnormal blood glucose.This result suggests that maternal exposure to PM2.5 may be a risk factor for diabetes in children or adolescents and therefore warrants further study.Especially considering that air pollution is very common throughout the world, this factor may have a profound impact on the future epidemic of obesity and type 2 diabetes.3 32 substances: Drinking drip coffee and driving away diabetes Observational studies have shown that drinking coffee is associated with a reduced risk of several noncommunicable diseases, including type 2 diabetes.Although the specific mechanism is not clear, it is speculated that many substances in coffee, such as caffeine, phenolic compounds, diterpenoids, and phytosterols, etc., may regulate the body’s glucose and lipid metabolism and inflammation levels to achieve preventionOf type 2 diabetes.Recent studies have used metabolomics to detect biomarkers after drinking coffee and drip coffee, respectively, pointing out that there are significant differences between the two, of which 32 biomarker levels changed by drip coffeeMay be the key to preventing type 2 diabetes.The study was published in J Internal Medicine.The study included participants in the Vasterbotten intervention program, using a non-targeted metabolomics approach to analyze the baseline and 10-year blood samples of 421 pairs of case-control participants and estimated coffee brewing and drip coffee using a food frequency surveyIntake.The brewed coffee refers to coffee obtained by boiling coffee powder together with water, and the content of diterpenoids in the coffee is much higher than that of drip coffee.A total of 24 biomarkers were found to be related to brewing coffee (0.1 ≤ | r | ≤ 0.51), and 32 biomarkers were related to drip coffee (0.1 ≤ | r | ≤ 0.36). These substances can be accurately detected by testingDetermine the type of coffee the participants drink..
Analysis of the risk of type 2 diabetes found that only drip coffee had a significant negative correlation with reduced risk of type 2 diabetes.For each standard deviation increase in biomarker levels, the corresponding risk will decrease by 15% (OR 0.85, 95% CI 0.72-1.00); the risk of the highest 1/4 population can decrease by 58% (0.42, 0.23-0.75) However, boiling coffee intake was not related to the risk of type 2 diabetes (1.02, 0.83-1.26; 1.03, 0.58-1.83).This result is consistent in the analysis using biomarkers and the analysis using the food frequency questionnaire. Drip coffee also appears to be associated with a reduced risk of type 2 diabetes (0.86, 0.70-1.05; 0.59, 0.33-1.04).Researchers believe that brewing coffee does not reduce the risk of type 2 diabetes, which may be related to the lack of adequate coffee or the insufficient protective effect of this type of coffee. The diterpenoids cafestol in brewing coffee may evenIt is also associated with elevated LDL cholesterol, triglycerides, and blood pressure.Previous research has suggested that the protective effect of coffee on type 2 diabetes may be related to the role of chlorogenic acid and polyphenols in regulating glucose and lipid metabolism and inflammatory responses.These substances are found in higher levels in drip coffee and lack of such substances in brewed coffee, which may be the reason that drip coffee alone can reduce the risk of type 2 diabetes.The above content is only authorized by for exclusive use, please do not reprint without authorization of the copyright party.


The author ouyangshaoxia