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How to encourage healthy liver cells to fight cancer?

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A study conducted at the VIB-KU Leuven Cancer Biology Center found that healthy tissues surrounding liver tumors activated defense mechanisms that inhibit tumor growth.Notably, the researchers found that excessive activation of this mechanism in the liver triggered the elimination of multiple types of liver tumors in mice.The findings identified a new strategy for combating liver cancer, and the findings were published in the journal Science.Current chemotherapy is designed to kill rapidly proliferating cancer cells.However, because cancer cells quickly develop resistance, this treatment is usually only temporarily effective.Today, other methods, such as immunotherapy, do not target tumor cells themselves, but activate the natural defenses of the immune system.The study led by Professor Georg Halder of VIB-KU Leuven Cancer Biology Center showed that not only the immune system but also normal liver cells surrounding liver tumors have the ability to kill tumor cells.When they activated this new mechanism in mice with liver tumors, the mice survived significantly longer and the tumors were greatly reduced.Professor Halder said: “Although studies show that such an anti-tumor mechanism exists, it is unclear exactly how activated liver cells cause the elimination of cancer cells, but this is obviously a very important issue that we are currently studying.”Tumor tissue of cancer patients and mouse models of liver cancer, scientists have found that YAP and TAZ genes are activated around liver tumors, driving the development of antitumor mechanisms.This finding is surprising because YAP and TAZ are often highly expressed in other types of human cancers, and they drive tumor cell proliferation and survival.The lead author of the paper, Iván Moya, said: “Traditionally, tumor-promoting genes have anti-tumor functions, which completely changes our view of cancer genes and their functions in normal tissues.” Although this study showsThis anti-tumor mechanism can kill tumors and metastases in the liver, but it is unclear whether similar mechanisms can be activated in other organs.Co-first author Stephanie Castaldo said: “Given the anti-tumor effect of YAP-activated liver cells, our findings may provide groundbreaking insights for a new type of combat strategy.” The above content is licensed exclusively to 39HealthNet, and is not copyrightedAuthorized please do not reprint.

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