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CANCER

Three signs indicate that bowel cancer has reached the middle and late stage!

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“Hey!” The quiet atmosphere of the office was suddenly destroyed by a fart.”Pharaoh, it’s you again!” “Oh, I am really embarrassed. I have eaten too much sweet potato last night, and I can’t control it.” Pharaoh scratched his head, not too embarrassed.”Fart fart doesn’t matter, it means you are healthy, you can’t put out the fart, it’s dangerous.” I asked Jun to come up from the corner.Xiao Ai, I heard, “Hey, is there such a saying? Good question, you can tell everyone about it!” We all have seen similar situations more or less, sometimes we want to fart but always feel blocked.Not coming out.If you have a feeling of bulging in the anus, but there is no gas, then we must be vigilant about the health of the intestines.Niu Jianhai, the chief physician of the First Hospital of Baoding City, said that anal bulge is likely to be caused by rectal mucosal fall or ulcerative colorectal inflammation.”There is no fart can not be released” is likely to be “intestinal obstruction”, more serious, it will be a sign of colorectal cancer, so in the case of such a situation, patients should go to the hospital for colonoscopy and other examinations.Why is it that “there is no skin to put out?””There is no fart to put out”, and there is usually a problem with the intestines.Intestinal obstruction, as the name suggests, the intestines are not smooth, blocked, is the most common surgical emergency.When the intestines pass through the obstacle, the contents of the stomach will be trapped and accumulated in the intestines, causing the intestines to swell and develop lesions.Many middle-aged and elderly people, with age, digestive function, will cause intestinal obstruction.Acute intestinal obstruction is rapid and difficult to diagnose, especially for some older patients, with degraded cardiopulmonary function and dysfunction, resulting in more deaths in patients with intestinal obstruction.In many cases, intestinal infarction is caused by tumor growth in the intestinal lumen, resulting in a gradual decrease in intestinal space.However, due to the long growth period of the intestinal tumor, the early tumor does not immediately cause symptoms of the body’s disease. It usually takes one to two weeks to be found around the intestinal wall, so when the tumor occurs and causes intestinal infarction, the tumor is predicted.It has been growing for a while.At this time, the patient went to the hospital because he was uncomfortable, but he had already missed the best treatment opportunity.Therefore, elderly people with gastrointestinal dysfunction or poor digestive function need to pay attention to gastrointestinal health.There is flatulence in the abdomen, and the gas is not discharged smoothly. When the “fart is not released”, it is necessary to increase the vigilance against the tumor in the intestine.”Can there be a fart can not be released” will be colorectal cancer?”If you can’t put it out,” you should consider the problem of intestinal obstruction. Then, will intestinal obstruction develop into intestinal cancer?In fact, the cause of intestinal cancer is more complicated, and personal bad eating habits and eating habits are the main incentives, and also have a certain relationship with family genetic history.When suffering from intestinal cancer, the tumor in the intestine can cause intestinal patency, hinder intestinal activity, and intestinal obstruction.However, intestinal obstruction is not necessarily the cause of the tumor, and any problem that causes poor intestinal activity can be the cause of intestinal obstruction.Prevention of bowel cancer, starting from these small things Although the diagnosis of bowel cancer is more difficult, but when we have intestinal lesions, we can be vigilant as soon as possible, promptly seek medical treatment for the risk of bowel cancer.As intestinal cancer deteriorates, symptoms such as abdominal pain, intestinal obstruction, and blood in the stool may occur.Therefore, when these symptoms appear, the public needs to have a sense of prevention, vigilance, and timely check medical treatment.At present, the main treatment for intestinal cancer is: laboratory examination, endoscopy, biopsy and exfoliative cytology.Laboratory tests can be used to effectively understand the patient’s intestinal condition through routine blood tests and blood tests.Endoscopy is more common. Colonoscopy can check the condition of the colon, which is more accurate than X-ray. The CEA method (blood tumor marker carcinoembryonic antigen) can effectively judge the tumor condition; it has the most early stage cancer and cancer.The significance of decisive diagnosis is biopsy.For the prevention of bowel cancer, Wu Weidong, deputy director of the First People’s Hospital affiliated to Shanghai Jiaotong University, gave several comments: First, we must pay attention to reducing the intake of high-fat and high-protein foods, increasing cellulosic foods; paying attention to intestinal health,Don’t shy your bowel movements, “put with your fart”; smoke and drink less to ensure sleep time and quality; and good habits and exercise will help improve your physical fitness.These measures are good for everyone to prevent bowel cancer.References: 1, “unexplained intestinal obstruction, the original small intestine tumor”. Health News. 2014-07-03.2, “different parts of colorectal cancer, what are their symptoms.” Life Times. 2017-10-27.3, “large intestineCan cancer be prevented?》. CCTV. 2018-04-03.

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CANCER

The palm of your hand is like a tripe. How do you get the clues of cancer from your skin?

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The skin is a mirror of good health, which reflects whether the machine is working properly.Recently, the New England Journal of Medicine published such a case. The palm of the patient’s palm is shaped like a hot pot. It is something to be eaten. What is going on?Patient profile: Female, 73 years old, had a smoking history of 30 packs. The first time in the palm of the hand, itching and pain were found in the dermatology clinic.The patient has been complaining of cough for one year and has lost 5 kg in the past 4 months.Physical examination revealed a velvety appearance and wrinkles on the palm surface, and her hand wrinkles also showed a clear boundary.This situation is called “carotine palm”, and the diseases closely related to it are cancer, especially lung cancer and stomach cancer.CT scan revealed irregular nodules in the left upper lobe, mediastinal lymphadenopathy, and biopsy specimens confirmed adenocarcinoma.The patient then received chemotherapy and radiation therapy.”Cornfoot” can be solved by treating potential cancer.However, the patient’s lesion did not resolve with chemotherapy or with a 10% urea ointment.The patient progressed with cancer six months after the visit and started a second-line chemotherapy regimen.The skin manifestations of malignant tumors are direct spread of invasive or metastatic skin, such as breast cancer, lung cancer, stomach cancer, kidney cancer, esophageal cancer, colorectal cancer, and blood system malignant tumors.It is a paraneoplastic skin manifestation, such as dermatomyositis, malignant acanthosis, sweet syndrome, paraneoplastic pemphigus, and other genetic syndromes that coexist with tumors.Understanding and understanding the skin manifestations associated with malignant tumors can help diagnose potential tumors.1. Malignant tumors Skin metastasis of malignant tumors refers to the pathological changes of malignant tumors that are secondary to the skin through blood circulation or lymphatic circulation, tissue gap diffusion or surgical implantation, which is the late manifestation of cancer, and a few may be the first stage of malignant tumors.Symptoms, domestic literature reports that 10% to 18% of patients with skin metastases are the first symptoms of the tumor, which can provide clues for the discovery and diagnosis of primary tumors.Once a skin metastasis occurs in a malignant tumor, it often indicates that the tumor cells are extensively infiltrated and the body’s immune function is severely degraded, sometimes accompanied by metastasis of other organs, and the prognosis is poor.In the treatment, it is mainly for radiotherapy and chemotherapy for primary tumors.1.Common sources of skin metastases: The primary cancer of women with skin metastases is most common in breast cancer, and other include gastric cancer, rectal cancer, lung cancer, ovarian cancer and kidney cancer.The primary cancer of male patients with metastatic carcinoma of the skin is most common in lung cancer. Others include bladder cancer, esophageal cancer, gastric cancer, colon cancer, rectal cancer, pancreatic cancer, kidney cancer and malignant melanoma.2.Clinical manifestations of skin metastases: Clinically, skin metastases can be single or multiple, more common in the chest, abdomen, shoulders, back, scalp, vulva, etc., and can also be seen in the limbs.Skin lesions often appear as skin color or dark red round or oval nodules, lumps, invasive erythema, hard texture, poor mobility, smooth or broken surface, generally no obvious symptoms, a few have pain.3.Histopathological changes in skin metastatic carcinoma: The histopathological manifestations of skin metastases vary from tumor tissue to tissue, but have some common features, namely, stellate-shaped tissue cells between the dermis and subcutaneous tissue.There are similar cell clusters in the lumen of the tube or venule.4.Skin leukemia: The skin infiltration of malignant blood cells is skin leukemia, which is caused by leukemia cells infiltrating the skin. Most of them are secondary, which can be expressed as papules, nodules, plaques, masses, etc. The histological features of infiltrating cells are consistent with the primary disease..There are also leukemias with rash as the first symptom, which should be taken seriously.Second, paraneoplastic dermatological paraneoplastic skin including a group of non-genetic skin diseases with visceral tumors, such as dermatomyositis, malignant acanthosis, Sweet syndrome, paraneoplastic pemphigus, acquired ichthyosis,Necrotic loosening erythema, Leser-Trelat sign, gangrenous pyoderma, skin amyloidosis, etc., are clinical syndromes in which malignant visceral tumors coexist with inflammatory reactions of the skin. The understanding of these diseases can be visceral malignant tumors.Early diagnosis and diagnosis provide opportunities.1.Dermatomyositis: The proportion of dermatomyositis associated with malignant tumors, reported in the literature is 15% to 60%, the incidence of tumors increases with age, more common in patients over 40 years old.Domestic and foreign literature reports that dermatomyositis occurs before malignant tumors, and both occur simultaneously or malignant tumors precede dermatomyositis. The accompanying tumors are more common in lung cancer, nasopharyngeal cancer, breast cancer, ovarian cancer, stomach cancer, liver cancer,Prostate cancer, kidney cancer, leukemia, etc.Patients with dermatomyositis appear as bright red, red or brown-red diffuse spots, and the slides can be regressed, called malignant erythema.When it occurs on the face, it is characterized by burgundy plaques, inclusions of punctate pigmentation spots, and agglomerated capillaries.The appearance of malignant erythema may be highly correlated with malignant tumors.2.Malignant acanthosis nigricans: Acanthosis nigricans with malignant tumors is called malignant acanthosis nigricans, 20% appear before tumors, and the rest appear after tumors.Acanthosis nigricans manifest as pigmentation and velvety appearance in the skin folds.Compared with benign acanthosis nigricans, malignant acanthosis nigricans has a short course of disease, rapid development, and progressive, more common in middle-aged and elderly patients, clinical symptoms such as rough skin, pigmentation and papilloma-like lesions of the skin are extensive and significant, and palmarCharacteristic velvet-like or bovine-like changes.The bovine-like palm is a characteristic manifestation of malignant acanthosis nigricans, which is common in gastric adenocarcinoma and lung cancer. Other tumors occur in the uterus, breast, ovary and liver.Sweet syndrome: Sweet syndrome, acute febrile neutrophilic dermatosis, with fever, increased peripheral white blood cell count, painful red papules, nodules, plaques, and mature neutrality distributed in the superficial dermisA reactive skin disease characterized by granulocyte infiltration, which may be associated with malignant tumors, is associated with malignant tumors, of which 85% are hematological tumors.Therefore, patients with a diagnosis of Sweet syndrome should be further systematically examined to check for possible malignant tumors.4.Paraneoplastic pemphigus: Paraneoplastic pemphigus is an autoimmune disease associated with tumors, and the patient can produce IgG autoantibodies that recognize epidermal adhesion proteins (proteins in desmosome and hemidesmosome).Almost all patients in this group have extensive and severe lip and oral mucosal erosion or ulceration. In some patients, the ocular membrane and genital mucosa also have erosions and ulcers at the same time; the skin lesions are pemphigus-like blisters, lichen planus and polymorphic erythema.The rash is more common, and the erythematous lesion of the erythema is characteristic.The most common tumor associated with paraneoplastic pemphigus in China is Castleman’s disease. In addition, fibrous tissue lymphoma, diffuse large B-cell lymphoma, and thymoma can be seen.The most important measure for the treatment of paraneoplastic pemphigus is early detection and complete removal of the tumor, and timely termination of the production of pathogenic antibodies is the key to reducing mortality.For patients with benign tumor resectable, resection of the tumor will improve symptoms and relieve the disease; for patients with malignant tumors, the treatment of resection of the tumor often does not affect the activity of the disease, and the mortality rate is high.5.Acquired ichthyosis: Adult acquired ichthyosis may be associated with malignancy.It appears as a scale of diffuse white and brown diamonds on the torso and extremities, and the edges are raised.Histology showed normal hyperkeratosis, thinning or lack of granular layers.70% to 80% of the malignant tumors associated with acquired ichthyosis are Hodgkin’s lymphoma, and also associated with non-Hodgkin’s lymphoma, multiple myeloma, and leukemia.Necrotic loosening erythema: is a paraneoplastic skin syndrome characterized by recurrent necrotic erythema, often accompanied by glucagonoma, is a glucagonoma syndromeThe most characteristic skin manifestations are also the primary diagnostic basis for most cases.The clinical manifestations of the facial, abdomen, thigh, perianal and perioral ring of migratory erythema, surface erosion, exudation, scarring, a centrifugal expansion.Once the glucagonoma is diagnosed, it should be removed as soon as possible.7.Leser-Trelat sign: Leser-Trelat signs sudden sudden increase or increase in lesions of sudden seborrheic keratosis or seborrheic keratosis, often complicated by visceral malignancies.Gastrointestinal adenocarcinoma and lymphoproliferative diseases are common in the combined tumors, but pregnancy and some benign tumors are also associated with this disease.For patients with sudden and intensive seborrheic keratosis with pruritus in middle-aged and elderly patients, the possibility of the Leser-Trelat sign should be considered, and detailed examination should be performed to detect possible malignant tumors.8.Other paraneoplastic skin diseases: Other paraneoplastic skin diseases including gangrenous pyoderma, skin amyloidosis, progressive necrotizing yellow granuloma, sclerosing mucinous edema, paraneoplastic kyphosis, carcinoid syndromeWait.It is worth noting that the long-term pruritus of the elderly may be a concomitant manifestation of malignant tumors, and relevant examinations should be completed to detect possible malignant tumors.Third, the genetic syndrome associated with malignant tumors.
Including some very rare genetic syndromes, such as Bagex syndrome, Bannayan-Zonana syndrome, Gardner syndrome, sputum-like basal cell carcinoma syndrome, etc., clinically rare, not to repeat.In summary, the skin is the largest organ in the human body. Many malignant tumors can show specific or non-specific skin lesions on the skin. Comprehensive medical history collection, physical examination and auxiliary examination can help to find potential good early detection.Malignant tumor.At the same time, the study of skin changes will help to further clarify the pathophysiological characteristics of the tumor and help early detection and treatment of the tumor. , please do not reprint without the authorization of the copyright owner.

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